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Prolonged survival in motor neuron disease: a descriptive study of the King's database 1990-2002
- Source :
- Journal of Neurology, Neurosurgery & Psychiatry. 74:995-997
- Publication Year :
- 2003
- Publisher :
- BMJ, 2003.
-
Abstract
- Motor neuron disease is a clinically heterogeneous disease with significant differences in survival. The authors have characterised a subset of long term survivors seen in a tertiary clinic over a 12 year period in terms of clinical variables and demographics, comparing them with short term survivors and the remaining population. Thirty of 769 patients survived more than 10 years, corresponding to 4% of the total population. Significantly younger onset of disease symptoms and a predominance of pure upper motor neuron signs at presentation characterised the long term survivors, but factors traditionally regarded as being associated with poor prognosis were also well represented. For a few people with motor neuron disease there remains the hope, whatever the initial presentation, that their subsequent survival will be longer than expected.
- Subjects :
- Adult
Male
medicine.medical_specialty
Pediatrics
Neuromuscular disease
Databases, Factual
Survival
Population
Short Report
Disease
Cohort Studies
Risk Factors
Epidemiology
medicine
Humans
Age of Onset
Motor Neuron Disease
education
Aged
education.field_of_study
business.industry
Middle Aged
Motor neuron
Prognosis
medicine.disease
Surgery
Psychiatry and Mental health
medicine.anatomical_structure
Female
Neurology (clinical)
Age of onset
business
Motor neurone disease
Cohort study
Subjects
Details
- ISSN :
- 00223050
- Volume :
- 74
- Database :
- OpenAIRE
- Journal :
- Journal of Neurology, Neurosurgery & Psychiatry
- Accession number :
- edsair.doi.dedup.....407b4274b62d1333a4ddf8f9c79f2988