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Supplementary Figure S4 from AZD4573 Is a Highly Selective CDK9 Inhibitor That Suppresses MCL-1 and Induces Apoptosis in Hematologic Cancer Cells

Authors :
Lisa Drew
Stephen E. Fawell
Michael Zinda
David M. Weinstock
Raphael Koch
Jamal C. Saeh
Wenlin Shao
Clive S. D'Santos
Chandra Sekhar Reddy Chilamakuri
Valar Nila Roamio Franklin
Nancy Su
Petar Pop-Damkov
Maryann San Martin
Steven W. Criscione
Douglas Ferguson
Theresa Proia
Scott Boiko
Justin Cidado
Publication Year :
2023
Publisher :
American Association for Cancer Research (AACR), 2023.

Abstract

Intermittent dosing of AZD4573 drives regression of hematological tumor xenografts as predicted by a PK/PD/efficacy model.

Details

Database :
OpenAIRE
Accession number :
edsair.doi.dedup.....4089f363c0de6f76d589e6db02857ef6
Full Text :
https://doi.org/10.1158/1078-0432.22473198.v1