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Macro domains as metabolite sensors on chromatin
- Source :
- Cellular and Molecular Life Sciences. 70:1509-1524
- Publication Year :
- 2013
- Publisher :
- Springer Science and Business Media LLC, 2013.
-
Abstract
- How metabolism and epigenetics are molecularly linked and regulate each other is poorly understood. In this review, we will discuss the role of direct metabolite-binding to chromatin components and modifiers as a possible regulatory mechanism. We will focus on globular macro domains, which are evolutionarily highly conserved protein folds that can recognize NAD(+)-derived metabolites. Macro domains are found in histone variants, histone modifiers, and a chromatin remodeler among other proteins. Here we summarize the macro domain-containing chromatin proteins and the enzymes that generate relevant metabolites. Focusing on the histone variant macroH2A, we further discuss possible implications of metabolite binding for chromatin function.
- Subjects :
- Models, Molecular
Computational biology
Biology
Chromatin remodeling
Epigenesis, Genetic
Histones
Cellular and Molecular Neuroscience
Macro domain
Histone H1
Histone H2A
Animals
Humans
Sirtuins
Histone code
Molecular Biology
ChIA-PET
Pharmacology
Cell Biology
NAD
Chromatin
Protein Structure, Tertiary
Biochemistry
Molecular Medicine
Poly(ADP-ribose) Polymerases
Bivalent chromatin
Subjects
Details
- ISSN :
- 14209071 and 1420682X
- Volume :
- 70
- Database :
- OpenAIRE
- Journal :
- Cellular and Molecular Life Sciences
- Accession number :
- edsair.doi.dedup.....4094e2a1372127f8fac01fdac39e2b07