Back to Search
Start Over
Epigenetics of paediatric acute myeloid leukaemia
- Source :
- British journal of haematologyReferences. 188(1)
- Publication Year :
- 2019
-
Abstract
- Comprehensive cataloguing of the acute myeloid leukaemia (AML) genome has revealed a high frequency of mutations and deletions in epigenetic factors that are frequently linked to treatment resistance and poor patient outcome. In this review, we discuss how the epigenetic mechanisms that underpin normal haematopoiesis are subverted in AML, and in particular how these processes are altered in childhood and adolescent leukaemias. We also provide a brief summary of the burgeoning field of epigenetic-based therapies, and how AML treatment might be improved through provision of better conceptual frameworks for understanding the pleiotropic molecular effects of epigenetic disruption.
- Subjects :
- Adolescent
business.industry
Hematology
Normal haematopoiesis
Bioinformatics
Epigenesis, Genetic
Hematopoiesis
03 medical and health sciences
Leukemia, Myeloid, Acute
0302 clinical medicine
Drug Resistance, Neoplasm
hemic and lymphatic diseases
030220 oncology & carcinogenesis
Mutation
Medicine
Humans
Epigenetics
Treatment resistance
Myeloid leukaemia
business
Child
030215 immunology
Subjects
Details
- ISSN :
- 13652141
- Volume :
- 188
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- British journal of haematologyReferences
- Accession number :
- edsair.doi.dedup.....40b07908b77128380b1c31b9614d4422