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First-order relatives of schizophrenic patients are not impaired in the Continuous Performance Test
- Source :
- Journal of Clinical and Experimental Neuropsychology. 32:481-486
- Publication Year :
- 2009
- Publisher :
- Informa UK Limited, 2009.
-
Abstract
- Sustained attention deficits measured by the Continuous Performance Test (CPT) have been reportedly proposed as an endophenotype of schizophrenia. One requirement for an endophenotype is that unaffected first-order relatives must show deteriorated performance compared to healthy controls. We investigated 56 schizophrenic patients, 33 nonaffected first-order relatives, and 36 healthy controls in a degraded and an undegraded version of the CPT of the AX type. Performance of relatives and controls was roughly identical whereas schizophrenic patients performed worse right from the beginning. These results add further evidence that a deficit in the CPT performance is not an endophenotype of schizophrenia in accordance with previous studies.
- Subjects :
- Nonpsychotic Relatives
Parents
Adult
Male
medicine.medical_specialty
Psychosis
Psychometrics
Schizotypy
Neuropsychological Tests
Audiology
Neuroleptic-Naive
Young Adult
medicine
Sustained Attention Deficits
Humans
Family
Psychiatry
Signal-Detection
medicine.diagnostic_test
Siblings
Continuous Performance Test
Cognition
Neuropsychological test
Middle Aged
First order
medicine.disease
Sustained attention
Cognitive functions
Cognitive Deficits
Clinical Psychology
Neurology
First-order relatives
Attention Deficit and Disruptive Behavior Disorders
Schizophrenia
Endophenotype
Endophenotypic Marker
Female
Schizophrenic Psychology
Neurology (clinical)
1St-Degree Relatives
Cognition Disorders
Psychology
Subjects
Details
- ISSN :
- 1744411X and 13803395
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical and Experimental Neuropsychology
- Accession number :
- edsair.doi.dedup.....40d7c66ef7165bcf83e47c483587fb9b