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Haemophilia early arthropathy detection with ultrasound and haemophilia joint health score in the moderate haemophilia (MoHem) study
- Source :
- Haemophilia : the official journal of the World Federation of HemophiliaREFERENCES. 27(2)
- Publication Year :
- 2020
-
Abstract
- Introduction Detection of early arthropathy is crucial for the management of haemophilia, but data on moderate haemophilia are limited. Therefore, we evaluated joint health and treatment modalities in Nordic patients with moderate haemophilia A (MHA) and B (MHB). Aim To explore and compare the Haemophilia Early Arthropathy Detection with Ultrasound (HEAD-US) and Haemophilia Joint Health Score (HJHS) to detect early arthropathy in moderate haemophilia. Methods A cross-sectional, multicentre study covering Nordic patients with MHA and MHB. Arthropathy was evaluated by HEAD-US and HJHS 2.1. Results We assessed 693 joints in 118 patients. HEAD-US scores (medians [interquartile ranges]) were as follows: elbows 0 points (0-0), knees 0 (0-0) and ankles 0 (0-1). Respectively, by HJHS: elbows 0 (0-1), knees 0 (0-1) and ankles 0 (0-1). Cartilage (14%) and bone (13%) were most commonly affected by HEAD-US. Frequent HJHS findings were crepitus on motion in knees (39%), and loss of flexion (23%) and extension (13%) in ankles. HEAD-US correlated strongly with HJHS (elbows r = .70, knees r = .60 and ankles r = .65), but 24% had discordant scores. Joints with HJHS zero points, 5% captured HEAD-US >= 1 point. Moreover, 26% had HJHS findings without HEAD-US pathology. Notably, 31% of knees had crepitus on motion and normal HEAD-US. Conclusion Overall, the joints attained low scores implying good joint health. HEAD-US correlated strongly with HJHS. In 5%, HEAD-US detected subclinical pathology. Crepitus on motion was frequently reported despite normal HEAD-US, thus not necessarily reflecting arthropathy. HEAD-US therefore improves the joint assessment in moderate haemophilia.
- Subjects :
- musculoskeletal diseases
medicine.medical_specialty
Moderate haemophilia A
030204 cardiovascular system & hematology
Haemophilia
Hemophilia A
03 medical and health sciences
0302 clinical medicine
Interquartile range
Internal medicine
Arthropathy
joint score
Medicine
Humans
Health score
Genetics (clinical)
Subclinical infection
Ultrasonography
Crepitus
ultrasound
business.industry
Arthritis
Ultrasound
Hematology
General Medicine
medicine.disease
Cross-Sectional Studies
3121 General medicine, internal medicine and other clinical medicine
prophylaxis
medicine.symptom
Joint Diseases
business
arthropathy
moderate haemophilia B
moderate haemophilia A
030215 immunology
Subjects
Details
- ISSN :
- 13652516 and 13518216
- Volume :
- 27
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Haemophilia : the official journal of the World Federation of HemophiliaREFERENCES
- Accession number :
- edsair.doi.dedup.....40e42a4d16e2adeb72f20c43c881d60f