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Plant Polyphenols Inhibit Benzoyl Peroxide-Induced Superoxide Anion Radical Production and Diacylglyceride Formation in Murine Peritoneal Macrophages
Plant Polyphenols Inhibit Benzoyl Peroxide-Induced Superoxide Anion Radical Production and Diacylglyceride Formation in Murine Peritoneal Macrophages
- Source :
- Nutrition and Cancer. 35:207-211
- Publication Year :
- 1999
- Publisher :
- Informa UK Limited, 1999.
-
Abstract
- Naturally occurring plant polyphenols, which include ellagic acid (EA), tannic acid (TA), caffeic acid (CA), and ferulic acid (FA), were tested for their superoxide anion radical (SOR)-scavenging activities. SOR were produced by interaction of the tumor promoter benzoyl peroxide (BPO) with murine peritoneal macrophages in vitro. The levels of SOR were assessed microscopically by counting the number of formazan-positive cells per 250 cells produced by the reduction of nitro blue tetrazolium. BPO at a concentration of 15 micrograms/1.85 x 10(6) cells/0.5 ml induced maximum formation of SOR in resident and thioglycollate-elicited cells. All the tested polyphenols were able to inhibit the formation of SOR induced by the tumor promoter to a variable degree. Inhibition of BPO-induced SOR formation by polyphenols was in the following order: FATACAEA. BPO stimulated the accumulation of diacylglycerol (DAG) in resident and elicited macrophages with concurrent release of choline equivalents from macrophages. Polyphenols inhibited DAG accumulation, which paralleled the inhibition of choline equivalent release. FA was observed to be the most effective and EA the least effective inhibitor of SOR formation, DAG accumulation, and release of choline equivalents. It is likely that inhibition of SOR formation might be due to some interference in the cellular lipid metabolism and phospholipid equivalent deacylation and choline release.
- Subjects :
- Cancer Research
Coumaric Acids
Polymers
Medicine (miscellaneous)
Benzoyl peroxide
Choline
Diglycerides
Ferulic acid
Mice
chemistry.chemical_compound
Caffeic Acids
Ellagic Acid
Phenols
Superoxides
Tannic acid
medicine
Caffeic acid
Animals
Cells, Cultured
Diacylglycerol kinase
Flavonoids
Nutrition and Dietetics
Benzoyl Peroxide
Chemistry
Superoxide
Polyphenols
food and beverages
Free Radical Scavengers
Plants
Hydrolyzable Tannins
Oncology
Biochemistry
Polyphenol
Macrophages, Peritoneal
medicine.drug
Ellagic acid
Subjects
Details
- ISSN :
- 15327914 and 01635581
- Volume :
- 35
- Database :
- OpenAIRE
- Journal :
- Nutrition and Cancer
- Accession number :
- edsair.doi.dedup.....41004b8c09443e617b0c4fce0b17ebf1
- Full Text :
- https://doi.org/10.1207/s15327914nc352_17