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Age-related changes in auditory function of rhesus monkeys (Macaca mulatta)
- Source :
- Hearing Research. 142:131-140
- Publication Year :
- 2000
- Publisher :
- Elsevier BV, 2000.
-
Abstract
- The purpose of this study was to investigate the changes in auditory function associated with aging in rhesus monkeys ( Macaca mulatta ) as a model for age-related changes in humans. One advantage of using monkeys from the Wisconsin Regional Primate Research Center was that lifestyle factors such as diet and excessive noise exposure were controlled. Twenty younger (mean: 10 years, 9 months, S.D.=±6 months) and 20 older (mean: 25 years, 11 months, S.D.=±11 months) monkeys were used in this study. Cochlear function in these monkeys was measured with distortion product otoacoustic emissions (DPOAEs); neural function was measured with auditory brainstem responses (ABRs) and middle latency responses (MLRs). Older monkeys had (1) significantly smaller DPOAEs, (2) significantly smaller ABR peak amplitudes, and (3) significantly longer ABR peak latencies compared to younger monkeys. Overall, these results suggest that older monkeys have decreased cochlear and neural function to the level of the brainstem as compared to younger monkeys. The decrease in DPOAE level and the increase in age accounted for approximately 70% of the increase in peak IV latency.
- Subjects :
- Male
Senescence
Aging
medicine.medical_specialty
Otoacoustic Emissions, Spontaneous
Central nervous system
Otoacoustic emission
Audiology
Hearing
biology.animal
Evoked Potentials, Auditory, Brain Stem
Reaction Time
otorhinolaryngologic diseases
medicine
Animals
Primate
Auditory function
Perceptual Distortion
biology
Macaca mulatta
Sensory Systems
Electrophysiology
medicine.anatomical_structure
Auditory brainstem response
Female
sense organs
Brainstem
Psychology
Subjects
Details
- ISSN :
- 03785955
- Volume :
- 142
- Database :
- OpenAIRE
- Journal :
- Hearing Research
- Accession number :
- edsair.doi.dedup.....4126e7d9c2a482c3d48907827f1ab2a9