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Prion protein is associated with a worse prognosis of head and neck squamous cell carcinoma
- Source :
- Journal of Oral Pathology & Medicine. 50:985-994
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Background Head and neck squamous cell carcinoma (HNSC) etiopathogenesis remains unclear, and the biological changes with the activation of heat shock proteins (HSPs) and prion protein (PRNP) promoted by hypoxia in HNSC are undetermined. Objective This study investigates hypoxia's effect in lymph node metastasis by PRNP expression changes and its main partners. Methods The study combined a theoretical/cell culture study with a case-control study. First, bioinformatics and cell culture were performed. A case-control study was performed in a second step by comparing HNSC patients with and without lymph node metastasis. Analyses The Cancer Genome Atlas (TCGA) data source validate the theory in the global population study. Results Bioinformatics analysis suggests that hypoxia-inducible factor-1α (HIF1A) is associated with HSPA4, HSP90AA1, and PRNP expression. TCGA data validate the hypothesis that higher HSP90AA1, HSPA4, and PRNP are related to metastases and low survival. Herein, the cell study demonstrated that muted PRNP did not respond to hypoxia. Conclusions Our results collectively provide the first evidence that PRNP promotes HNSC lymph node metastasis progression through the upregulation of HSPA4, HSP90AA1, and HIF1A. Our findings may provide a molecular basis for the promoting Role of PRNP in HNSC progression.
- Subjects :
- Cancer Research
animal diseases
Cell
Prion Proteins
Pathology and Forensic Medicine
PRNP
HSPA4
03 medical and health sciences
0302 clinical medicine
Downregulation and upregulation
Heat shock protein
Biomarkers, Tumor
medicine
Humans
Squamous Cell Carcinoma of Head and Neck
business.industry
030206 dentistry
Prognosis
medicine.disease
Head and neck squamous-cell carcinoma
nervous system diseases
HIF1A
medicine.anatomical_structure
Otorhinolaryngology
Head and Neck Neoplasms
Cell culture
Case-Control Studies
030220 oncology & carcinogenesis
Cancer research
Periodontics
Oral Surgery
business
Subjects
Details
- ISSN :
- 16000714 and 09042512
- Volume :
- 50
- Database :
- OpenAIRE
- Journal :
- Journal of Oral Pathology & Medicine
- Accession number :
- edsair.doi.dedup.....41293431f3bc859028ac1daa134464a4
- Full Text :
- https://doi.org/10.1111/jop.13188