Association analysis between the OPG g.27667T>A genetic variant and bone mineral density in Chinese postmenopausal women

The purpose of this study was to investigate the association of the g.27667TA genetic variant in the osteoprotegerin (OPG) gene with bone mineral density (BMD) and osteoporosis. A total of 393 primary osteoporosis subjects and 402 healthy controls were recruited. The BMD of the femoral neck hip, lumbar spine (L2-4), and total hip were evaluated by Norland XR-46 dual-energy X-ray absorptiometry. The g.27667TA genetic variant was genotyped using created restriction site-polymerase chain reaction. Our data indicated significant differences in BMD of the femoral neck hip, lumbar spine (L2-4), and total hip among different genotypes. Individuals with the genotype TT had significantly higher BMDs than those of genotypes TA and AA (P0.05). Results from this study suggest that the g.27667TA genetic variant in the OPG gene is potentially related to BMD and osteoporosis in Chinese postmenopausal women.