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Epirubicin-induced QT prolongation, monomorphic ventricular tachycardia, and response to beta blockade in long QT syndrome type 2
- Source :
- HeartRhythm Case Reports
- Publication Year :
- 2020
- Publisher :
- Umeå universitet, Avdelningen för medicin, 2020.
-
Abstract
- Congenital long QT syndrome (LQTS) is a group of cardiac channelopathies that are manifested through changes in repolarization. Patients are at increased risk of malignant ventricular arrhythmia, triggered by early afterdepolarization (EAD).1 The primary treatment consists of beta-blockade.2 The relative efficacy of various beta-blockers is a matter of debate and may vary among the genotypes.3, 4, 5 A survey of experts reported that most considered nonselective beta-blockers to be more effective. However, there is limited high-quality evidence and current guidelines abstain from opinion on this matter.6,7 Key Teaching Points • Treatment of long QT syndrome (LQTS) patients with epirubicin may lead to a marked additional QT prolongation. • Treatment with epirubicin in previously asymptomatic LQTS patients may lead to ventricular arrhythmias. • Nonselective beta-blockers are often considered to be more effective than the selective ones in treatment of LQTS. This view is mainly based on expert opinion. The support in existing studies is weak and current guidelines offer no advice on the matter. • The nonselective beta-blocker propranolol is more effective in suppressing these arrhythmias than the selective beta-blocker metoprolol.
- Subjects :
- medicine.medical_specialty
Cancer therapy
medicine.drug_class
Long QT syndrome
Case Report
Anthracycline
Asymptomatic
QT interval
Afterdepolarization
Internal medicine
QT interval prolongation
Medicine
Repolarization
LQT2
Cardiac and Cardiovascular Systems
cardiovascular diseases
Beta-blocker
Beta blocker
Metoprolol
Epirubicin
Kardiologi
business.industry
medicine.disease
Long QT
Propranolol
Cardio-oncology
Cardiology
medicine.symptom
Cardiology and Cardiovascular Medicine
business
medicine.drug
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- HeartRhythm Case Reports
- Accession number :
- edsair.doi.dedup.....41477d413d43293fe1feaf63cd7d0f9e