Back to Search Start Over

Efficacy of Bagassa guianensis Aubl. extract against wood decay and human pathogenic fungi

Authors :
Bernard Thibaut
Didier Stien
Maxime Chevalier
Bruno Hérault
Alice M. S. Rodrigues
Jacques Beauchêne
Mariana Royer
Gaëtan Herbette
School of economics and mathematics
Southwestern University of Finance and Economics [Chengdu, China]
Spectropôle - Aix Marseille Université (AMU SPEC)
Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)
Mécanique de l'Arbre et du Bois (MAB)
Laboratoire de Mécanique et Génie Civil (LMGC)
Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)
Institut de Chimie des Substances Naturelles (ICSN)
Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)
Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)
Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Source :
International Biodeterioration and Biodegradation, International Biodeterioration and Biodegradation, Elsevier, 2012, 70 (1), pp.55-59. ⟨10.1016/j.ibiod.2011.10.016⟩, International Biodeterioration and Biodegradation, 2012, 70 (1), pp.55-59. ⟨10.1016/j.ibiod.2011.10.016⟩
Publication Year :
2012
Publisher :
Elsevier BV, 2012.

Abstract

International audience; Extractives that provide natural resistance to Bagassa guianensis Aubl. heartwood were examined. Soil-bed tests showed that the B. guianensis heartwood resistance was significantly reduced after ethyl acetate extraction, whereas methanol and especially water extractions improved the resistance. The ethyl acetate extract was submitted to a bioguided fractionation, and fractions were tested against one wood-destroying fungal strain (Pycnoporus sanguineus) and two human pathogenic fungal strains (Candida glabrata (yeast) and Trichophyton rubrum (filamentous dermatophyte)). Fraction F7, which exhibited the strongest antifungal activity, was subsequently fractionated by high performance liquid chromatography (HPLC). Six previously described compounds were isolated. Although the two moracins, 6-O-methyl-moracin N (3) and moracin N (4) were the most active against fungal strains with MIC values between 4 and 16 μg ml−1, the isolated compounds showed less or equivalent antifungal activity than the initial fraction. Possible synergism between compounds 3 and 4 and other secondary metabolites have been hypothesized. Our study demonstrated that this extract as a whole might be used as a wood preservation or antimycotic product.

Details

ISSN :
09648305 and 18790208
Volume :
70
Database :
OpenAIRE
Journal :
International Biodeterioration & Biodegradation
Accession number :
edsair.doi.dedup.....415b877b8416ad900951953b76a372db
Full Text :
https://doi.org/10.1016/j.ibiod.2011.10.016