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Antitussive effects of the H1-receptor antagonist epinastine in patients with atopic cough (eosinophilic bronchitis)
- Source :
- Arzneimittel-Forschung. 54(4)
- Publication Year :
- 2004
-
Abstract
- Chronic cough is the only symptom of eosinophilic bronchitis (EB). There is considerable overlap between EB and atopic cough. To investigate the antitussive effects of a histamine H1-recetor antagonist, epinastine hydrochloride (epinastine, CAS 80012-43-7, Alesion; 20 mg/day, once daily), cough scores, pulmonary function, capsaicin cough threshold, and bronchial hyperresonsiveness (BHR) to methacholine (MCh) were evaluated before and after a 4-week treatment with epinastine in patients with EB. In the epinastine group, the cough scores were decreased significantly (18.3 +/- 6.1 in week 1, 17.4 +/- 6.7 in week 2, 15.1 +/- 6.2 in week 3, 14.0 +/- 4.8 in week 4) in comparison with the value of 35.3 +/- 8.7 in week -2). The cough threshold for capsaicin improved from 1.70 +/- 3.04 micromol/l to 12.7 +/- 17.6 micromol/l in the epinastine group (p0.05; baseline vs. week 4) The bronchial hyperresponsiveness to MCh (Dmin) did not change significantly either in the epinastine or the placebo groups. The morning and evening peak expiratory flow rate (PEFR, L/min) did not change from the baseline period in either the epinastine or the placebo groups. These results suggested that epinastine may be useful for treating patients with EB and that histamine H1-receptor is related to the pathophysiology of coughing in EB.
- Subjects :
- Adult
Male
Allergy
Eosinophilic bronchitis
Epinastine
Muscarinic Agonists
Atopy
Epinastine Hydrochloride
Double-Blind Method
Dibenzazepines
Drug Discovery
medicine
Humans
Bronchitis
Methacholine Chloride
Aged
business.industry
Imidazoles
Middle Aged
medicine.disease
Respiratory Function Tests
Chronic cough
Antitussive Agents
Cough
Anesthesia
Histamine H1 Antagonists
Methacholine
Female
medicine.symptom
Bronchial Hyperreactivity
Capsaicin
business
medicine.drug
Subjects
Details
- ISSN :
- 00044172
- Volume :
- 54
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Arzneimittel-Forschung
- Accession number :
- edsair.doi.dedup.....4161751cb96f7aa36b8db6969e89e577