Intracoronary adenosine 5'-triphosphate as an alternative to papaverine for measuring coronary flow reserve

In conclusion, 50 μg of intracoronary ATP exhibited a vasodilator potency similar to that of papaverine without producing any marked changes in hemodynamics or a prolongation of the QTc. Intracoronary ATP may therefore be safer than papaverine for measuring CFR; more conclusive evidence about the safety of intracoronary ATP will have to await the conclusion of larger trials.