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The incidence of brain lesions in central precocious puberty: The main cause for Chinese boys was idiopathic
- Source :
- Clinical Endocrinology
- Publication Year :
- 2021
- Publisher :
- John Wiley and Sons Inc., 2021.
-
Abstract
- Objective Many studies show that brain lesions are the main cause of central precocious puberty (CPP) in males. However, the association rate has not been reported in China. This study aimed to assess the frequency of both abnormal and likely pathologic brain lesions by magnetic resonance imaging (MRI) in Chinese boys with CPP. Design This is a retrospective cross-sectional single-centre study. Patients 396 CPP boys were recruited from 2011 to 2019 in Children's Hospital, Zhejiang University School of Medicine, and 129 were eligible for our study. Measurements Diagnosis age, bone age, weight (kg), height (cm), puberty stage, MRI results and levels of sexual hormone were analysed. Results The number of CPP boys is increasing from 2011 to 2019 in China. Brain MRI findings were normal in 83.7% of CPP boys. Only 21 (16.3%) CPP boys were found with abnormal MRI findings including hamartoma, pineal cyst and other minor changes. Conclusion In China, there is an increasing trend of male CPP over the last decade and the main cause is idiopathic, rather than pathogenic brain lesions. Further investigations about the aetiology for CPP with pathological brain lesions are needed.
- Subjects :
- Male
Pediatrics
medicine.medical_specialty
China
Endocrinology, Diabetes and Metabolism
Central precocious puberty
prevalence
Puberty, Precocious
030209 endocrinology & metabolism
Gonadotropin-Releasing Hormone
03 medical and health sciences
0302 clinical medicine
Endocrinology
Pediatric Endocrinology
Internal medicine
medicine
Hamartoma
Humans
Pathological
Retrospective Studies
central precocious puberty
medicine.diagnostic_test
business.industry
Incidence (epidemiology)
brain lesions
Incidence
Brain
Magnetic resonance imaging
Bone age
medicine.disease
Chinese boys
body regions
Cross-Sectional Studies
030220 oncology & carcinogenesis
Etiology
3 Original Article ‐ Australia, Japan, Se Asia
ORIGINAL ARTICLES
business
psychological phenomena and processes
Hormone
Subjects
Details
- Language :
- English
- ISSN :
- 13652265 and 03000664
- Volume :
- 95
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Clinical Endocrinology
- Accession number :
- edsair.doi.dedup.....41a8779a20eaa4b5db475c855564fc20