Rational Design, Synthesis, in Vitro , and in Silico Studies of Chlorophenylquinazolin‐4(3 H )‐One Containing Different Aryl Acetohydrazides as Tyrosinase Inhibitors

Tyrosinase plays a pivotal role in the hyperpigmentation and enzymatic browning of fruit and vegetable. Therefore, tyrosinase inhibitors can be of interest in industries as depigmentation compounds as well as anti-browning agents. In the present study, a series of chlorophenylquinazolin-4(3H)-one derivative were rationally designed and synthesized. The formation of target compounds was confirmed by spectral characterization techniques such as IR