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The effect of age on blood pressure response by 4-week treatment perindopril
- Source :
- Clinical and Translational Science, Vol 14, Iss 6, Pp 2193-2199 (2021), Clinical and Translational Science, 14(6), 2193-2199. Wiley-Blackwell Publishing Ltd, Clinical and Translational Science
- Publication Year :
- 2021
-
Abstract
- Previous studies showed that postmenopausal women are more likely to have poorly controlled hypertension than men of the same age. Whether this is caused by inadequate treatment or poor response to antihypertensive agents remains unknown. The aim of this study is to analyze treatment response to the most potent renin angiotensin aldosterone system (RAAS) inhibitor perindopril in different age categories in women and men. Individual patient data were used from the combined European Trial on Reduction of Cardiac Events With Perindopril (EUROPA), Perindopril Protection Against Recurrent Stroke Study (PROGRESS), and Action in Diabetes and Vascular disease: Preterax and Diamicron-MR Controlled Evaluation (ADVANCE) trials, which include patients with vascular disease (n = 29,463). We studied the relative and absolute changes in systolic blood pressure (SBP) and diastolic blood pressure (DBP) during a 4-week run-in phase in which all patients were treated with the perindopril-based treatment in different age categories. In total, 8366 women and 21,097 men were included in the analysis. Women greater than 65 years of age showed a significantly smaller blood pressure reduction after perindopril treatment (2.8 mmHg [95% confidence interval {CI} = 0.1–5.5] less reduction compared to women ≤45 years, p = 0.039). In men, the SBP reduction after perindopril in patients greater than 55–65 and greater than 65 years was lower compared to the age category less than or equal to 45 years (adjusted mean difference >55–65: 2.8 mmHg [95% CI = 1.8–3.7], p 65: 3.7 mmHg [95% CI = 2.7–4.7], p
- Subjects :
- Adult
Male
medicine.medical_specialty
Blood Pressure
RM1-950
General Biochemistry, Genetics and Molecular Biology
Article
SDG 3 - Good Health and Well-being
Diabetes mellitus
Internal medicine
Renin–angiotensin system
Outcome Assessment, Health Care
medicine
Perindopril
Humans
General Pharmacology, Toxicology and Pharmaceutics
Antihypertensive Agents
Aged
Vascular disease
business.industry
General Neuroscience
Research
Age Factors
General Medicine
Articles
Middle Aged
medicine.disease
Confidence interval
Blood pressure
Ageing
ACE inhibitor
Cardiology
Female
Therapeutics. Pharmacology
Public aspects of medicine
RA1-1270
business
medicine.drug
circulatory and respiratory physiology
Subjects
Details
- Language :
- English
- ISSN :
- 17528054
- Volume :
- 14
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Clinical and Translational Science
- Accession number :
- edsair.doi.dedup.....41c641f7c7c9a9268d2b9b7a1265c8ff