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Whole blood manganese concentrations in dogs with primary hepatitis

Authors :
Richard J. Mellanby
R D Foale
Adam Gow
C. A. Burton
P. E. Frowde
C M Elwood
A Duncan
Scott Kilpatrick
A. M. L. Jacinto
S W Tappin
R Powell
Source :
Journal of Small Animal Practice. 55:241-246
Publication Year :
2014
Publisher :
Wiley, 2014.

Abstract

Objectives Increased whole blood manganese concentrations have been reported in humans with primary liver disease. Due to the neurotoxic effects of manganese, altered manganese homeostasis has been linked to the development of hepatic encephalopathy. Whole blood manganese concentrations are increased in cases of canine congenital portosystemic shunts, but it remains unclear whether dogs with primary hepatopathies also have altered manganese homeostasis. Methods Whole blood manganese concentrations were measured by graphite furnace atomic absorption spectrometry in 21 dogs with primary hepatitis, 65 dogs with a congenital portosystemic shunt, 31 dogs with non-hepatic illnesses and 18 healthy dogs. Results The whole blood manganese concentrations were significantly different between dogs with primary hepatitis, dogs with non-hepatic illnesses and healthy dogs (P=0·002). Dogs with primary hepatitis had significantly increased whole blood manganese concentrations compared with healthy dogs (P

Details

ISSN :
00224510
Volume :
55
Database :
OpenAIRE
Journal :
Journal of Small Animal Practice
Accession number :
edsair.doi.dedup.....41c9dd4e5634c02ba5d36714f8b9e154
Full Text :
https://doi.org/10.1111/jsap.12196