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Disturbed homeostasis of zinc and other essential elements in the prostate gland dependent on the character of pathological lesions
- Source :
- BioMetals. 22:1041-1049
- Publication Year :
- 2009
- Publisher :
- Springer Science and Business Media LLC, 2009.
-
Abstract
- Pathophysiological changes in the prostate take the form of benign prostate hyperplasia (BPH) and prostate adenocarcinoma (PCa). In prostate, zinc is particularly important to its normal functioning, especially in terms of the consequences of hormone disturbance. The aim of this study was to assess the levels of Zn, Cu, Ca, Mg, and Se in the prostate dependent on the character of patological changes. Zinc, copper, magnesium and calcium were determined by AAS and selenium with spectrofluorometric method. Zn levels in BPH patients were over twofold higher than in controls. On the other hand, in the patients with PCa, the levels of Zn were found almost three times lower than in BPH patients and by almost 50% lower than in controls. In this study, significant changes in the levels of other essential elements were observed. The results apparently confirm the disturbed homeostasis of zinc and other essential elements in the etiology of BPH and PCa.
- Subjects :
- Male
medicine.medical_specialty
Biopsy
Prostatic Hyperplasia
Down-Regulation
chemistry.chemical_element
Zinc
Adenocarcinoma
Calcium
urologic and male genital diseases
General Biochemistry, Genetics and Molecular Biology
Biomaterials
Selenium
Prostate cancer
Prostate
Internal medicine
medicine
Homeostasis
Humans
Magnesium
Aged
Aged, 80 and over
medicine.diagnostic_test
Chemistry
Spectrophotometry, Atomic
Metals and Alloys
Prostatic Neoplasms
Middle Aged
Hyperplasia
medicine.disease
Up-Regulation
Spectrometry, Fluorescence
Endocrinology
medicine.anatomical_structure
General Agricultural and Biological Sciences
Copper
Subjects
Details
- ISSN :
- 15728773 and 09660844
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- BioMetals
- Accession number :
- edsair.doi.dedup.....41d3ff18bd1f669ca4cc8f1a116e9649