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Genome-wide association analysis of secondary imaging phenotypes from the Alzheimer's disease neuroimaging initiative study
- Source :
- NeuroImage. 146:983-1002
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- The aim of this paper is to systematically evaluate a biased sampling issue associated with genome-wide association analysis (GWAS) of imaging phenotypes for most imaging genetic studies, including the Alzheimer’s Disease Neuroimaging Initiative (ADNI). Specifically, the original sampling scheme of these imaging genetic studies is primarily the retrospective case-control design, whereas most existing statistical analyses of these studies ignore such sampling scheme by directly correlating imaging phenotypes (called the secondary traits) with genotype. Although it has been well documented in genetic epidemiology that ignoring the case-control sampling scheme can produce highly biased estimates, and subsequently lead to misleading results and suspicious associations, such findings are not well documented in imaging genetics. We use extensive simulations and a large-scale imaging genetic data analysis of the Alzheimer’s Disease Neuroimag-ing Initiative (ADNI) data to evaluate the effects of the case-control sampling scheme on GWAS results based on some standard statistical methods, such as linear regression methods, while comparing it with several advanced statistical methods that appropriately adjust for the case-control sampling scheme.
- Subjects :
- Male
Genotype
Imaging genetics
Cognitive Neuroscience
Neuroimaging
Genome-wide association study
Computational biology
Disease
computer.software_genre
Polymorphism, Single Nucleotide
01 natural sciences
Article
010104 statistics & probability
03 medical and health sciences
0302 clinical medicine
Alzheimer Disease
Humans
Medicine
Computer Simulation
0101 mathematics
Genetic association
Sampling bias
business.industry
Brain
Reproducibility of Results
Magnetic Resonance Imaging
Phenotype
Neurology
Genetic epidemiology
Research Design
Case-Control Studies
Female
Data mining
business
computer
030217 neurology & neurosurgery
Genome-Wide Association Study
Alzheimer's Disease Neuroimaging Initiative
Subjects
Details
- ISSN :
- 10538119
- Volume :
- 146
- Database :
- OpenAIRE
- Journal :
- NeuroImage
- Accession number :
- edsair.doi.dedup.....41ea83774340f4b160d4a769370c00c7