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Anserine (beta-alanyl-3-methyl-L-histidine) improves neurovascular-unit dysfunction and spatial memory in aged AβPPswe/PSEN1dE9 Alzheimer’s-model mice
- Source :
- Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017), Scientific Reports
- Publication Year :
- 2017
- Publisher :
- Nature Publishing Group, 2017.
-
Abstract
- Anserine/carnosine supplementation improves cerebral blood flow and verbal episodic memory in elderly people, as we previously reported. Anserine’s buffering activity is superior to that of carnosine at neutral pH. In human sera, carnosine but not anserine is rapidly cleaved by carnosinase, limiting its effectiveness. This study examined the effects of anserine on AβPPswe/PSEN1dE9 Alzheimer’s disease (AD) model mice over 18-months old, an age at which these mice exhibit detectable memory deficits. We found that 8 weeks of anserine treatment completely recovered the memory deficits, improved pericyte coverage on endothelial cells in the brain, and diminished chronic glial neuroinflammatory reactions in these mice. These results suggest that anserine (beta-alanyl-3-methyl-L-histidine) supplementation improved memory functions in AD-model mice by exerting a protective effect on the neurovascular units, which are composed of endothelial cells, pericytes, and supporting glial cells.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Aging
Dipeptidases
Anserine
Carnosine
lcsh:Medicine
Article
03 medical and health sciences
chemistry.chemical_compound
Mice
0302 clinical medicine
Alzheimer Disease
Internal medicine
medicine
Presenilin-1
Elderly people
Animals
Humans
Neutral ph
lcsh:Science
Episodic memory
Spatial Memory
Multidisciplinary
Amyloid beta-Peptides
Beta-Alanyl-3-Methyl-L-Histidine
lcsh:R
Brain
Endothelial Cells
Neurovascular bundle
Disease Models, Animal
030104 developmental biology
Endocrinology
Cerebral blood flow
chemistry
Immunology
lcsh:Q
Pericytes
Neuroglia
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 7
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....41ed7ae94ab8383a7b51eb3504ed5c51