Back to Search
Start Over
Disease activity in multiple sclerosis studied by weekly triple-dose magnetic resonance imaging
- Publication Year :
- 1999
-
Abstract
- This study assessed whether dysfunction of the blood-brain barrier is an obligatory early event in lesion formation in multiple sclerosis. Dual-echo and T1-weighted magnetic resonance imaging after the injection of a triple dose (0.3 mmol/kg) of gadolinium-DTPA were obtained from ten patients with relapsing-remitting multiple sclerosis every week for 2 months. Sixty-four newly active lesions were detected by the two techniques. All the 44 new lesions seen on dual-echo scans enhanced during the early phases of their formation: 33 at their first appearance, 10 1 week before their appearance on the dual-echo scans, and one the week thereafter. When the every fourth (monthly) scan was analyzed, a total of 55 newly active lesions were detected (i.e., 14% active lesions would have been missed compared to the number found on weekly scanning). Thirty-one of them were detected by both dual-echo and triple-dose scans, 15 only by enhanced scans, and nine only by dual-echo scans. This study confirms that with highly sensitive magnetic resonance imaging techniques dysfunction of the blood-brain barrier is an obligatory early event in new lesion formation in relapsing-remitting multiple sclerosis.
- Subjects :
- Adult
Male
medicine.medical_specialty
Multiple Sclerosis
Neurology
Blood–brain barrier
Sensitivity and Specificity
Disease activity
Central nervous system disease
medicine
Humans
Neuroradiology
medicine.diagnostic_test
business.industry
Multiple sclerosis
Gadodiamide
Magnetic resonance imaging
Image Enhancement
medicine.disease
Magnetic Resonance Imaging
medicine.anatomical_structure
Blood-Brain Barrier
Disease Progression
Female
Neurology (clinical)
Nuclear medicine
business
Follow-Up Studies
medicine.drug
Subjects
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....41f634951066fce109a76b6edd9dc73f