Back to Search
Start Over
Evaluation of Malaria Urban Risk Using an Immuno-Epidemiological Biomarker of Human Exposure to Anopheles Bites
- Source :
- American Journal of Tropical Medicine and Hygiene, American Journal of Tropical Medicine and Hygiene, American Society of Tropical Medicine and Hygiene, 2018, 98 (5), pp.1353-1359. ⟨10.4269/ajtmh.17-0231⟩, American Journal of Tropical Medicine and Hygiene, 2018, 98 (5), pp.1353-1359. ⟨10.4269/ajtmh.17-0231⟩
- Publication Year :
- 2018
- Publisher :
- HAL CCSD, 2018.
-
Abstract
- International audience; Urban malaria is an underestimated serious health concern in African countries. This study aimed to evaluate the risk of malaria transmission in an urban area by evaluating the level of human exposure to Anopheles bites using an Anopheles salivary biomarker (gambiae Salivary Gland Protein-6 peptide 1 [gSG6-P1] peptide). Two multidisciplinary cross-sectional studies were undertaken in five sites of Bouaké city (three urban districts and two surrounding villages, used as control; Côte d’Ivoire) during the rainy season and the dry season. Blood samples were obtained from children 6 months to 14 years of age for immunological tests. The level of anti-gSG6-P1 immunoglobulin G (IgG) antibodies was significantly higher in the rainy season than the dry season in both urban and rural sites (P < 0.0001). Interestingly, children with the highest anti-gSG6-P1 IgG responses in the rainy season were infected by Plasmodium falciparum. Surprisingly, no difference of anti-gSG6-P1 IgG level was observed between urban and rural areas, for either season. The current data suggest that children in the urban city of Bouaké could be as highly exposed to Anopheles bites as children living in surrounding villages. The immunological biomarker of human exposure to Anopheles bites may be used to accurately assess the potential risk of malaria transmission in African urban settings.
- Subjects :
- Rural Population
Wet season
medicine.medical_specialty
Urban Population
030231 tropical medicine
Mosquito Vectors
Biology
03 medical and health sciences
0302 clinical medicine
Risk Factors
Virology
Environmental health
Anopheles
Epidemiology
Dry season
parasitic diseases
medicine
Animals
Humans
030212 general & internal medicine
Salivary Proteins and Peptides
Insect Bites and Stings
Plasmodium falciparum
Articles
medicine.disease
biology.organism_classification
[SDE.ES]Environmental Sciences/Environmental and Society
Malaria
3. Good health
Cote d'Ivoire
Cross-Sectional Studies
Infectious Diseases
Child, Preschool
Immunoglobulin G
Insect Proteins
Parasitology
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Seasons
Rural area
Risk assessment
Biomarkers
Subjects
Details
- Language :
- English
- ISSN :
- 00029637
- Database :
- OpenAIRE
- Journal :
- American Journal of Tropical Medicine and Hygiene, American Journal of Tropical Medicine and Hygiene, American Society of Tropical Medicine and Hygiene, 2018, 98 (5), pp.1353-1359. ⟨10.4269/ajtmh.17-0231⟩, American Journal of Tropical Medicine and Hygiene, 2018, 98 (5), pp.1353-1359. ⟨10.4269/ajtmh.17-0231⟩
- Accession number :
- edsair.doi.dedup.....41fdd938caef8bb34aaec7463472377d