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Risk Factors Associated With Cerebrovascular Recurrence in Symptomatic Carotid Disease: A Comparative Study of Carotid Plaque Morphology, Microemboli Assessment and the European Carotid Surgery Trial Risk Model
- Source :
- Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
- Publication Year :
- 2014
- Publisher :
- Blackwell Publishing Ltd, 2014.
-
Abstract
- Background The European Carotid Surgery Trial ( ECST ) risk model is a validated tool for predicting cerebrovascular risk in patients with symptomatic carotid disease. Carotid plaque hemorrhage as detected by MRI ( MRIPH ) and microembolic signals ( MES ) detected by transcranial Doppler ( TCD ) are 2 emerging modalities in assessing instability of the carotid plaque. The aim of this study was to assess the strength of association of MES and MRIPH with cerebrovascular recurrence in patients with symptomatic carotid artery disease in comparison with the ECST risk prediction model. Methods and Results One hundred and thirty‐four prospectively recruited patients (mean [ SD ]: age 72 [9.8] years, 33% female) with symptomatic severe (50% to 99%) carotid stenosis underwent preoperative TCD , MRI of the carotid arteries to assess MES , PH, and the ECST risk model. Patients were followed up until carotid endarterectomy, recurrent cerebral event, death, or study end. Event‐free survival analysis was done using backward conditional Cox regression analysis. Of the 123 patients who had both TCD and MRI , 82 (66.7%) demonstrated PH and 46 (37.4%) had MES . 37 (30.1%) cerebrovascular events (21 transient ischemic attacks, 6 amaurosis fugax, and 10 strokes) were observed. Both carotid PH ( HR =8.68; 95% CI 2.66 to 28.40, P MES ( HR =3.28; 95% CI 1.68 to 6.42, P =0.001) were associated with cerebrovascular event recurrence. Combining MES and MRIPH improved the strength of association ( HR =0.74, 95% CI 0.65 to 0.83; P ECST risk model was not associated with recurrence ( HR =0.86; 95% CI 0.45 to 1.65; P =0.65). Conclusions The presence of carotid plaque hemorrhage is better associated with recurrent cerebrovascular events in patients with symptomatic severe carotid stenosis than the presence of microembolic signals; combining MES and MRIPH , further improves the association while the ECST risk score was insignificant.
- Subjects :
- Male
medicine.medical_specialty
Ultrasonography, Doppler, Transcranial
medicine.medical_treatment
Carotid endarterectomy
Kaplan-Meier Estimate
Magnetic resonance angiography
carotid arteries
Recurrence
Risk Factors
Carotid artery disease
medicine
magnetic resonance imaging
Humans
Carotid Stenosis
cardiovascular diseases
Prospective Studies
Stroke
Original Research
cerebrovascular embolism
Aged
Proportional Hazards Models
Endarterectomy, Carotid
Framingham Risk Score
medicine.diagnostic_test
business.industry
Amaurosis fugax
medicine.disease
Transcranial Doppler
Stenosis
relative risk
Intracranial Embolism
cardiovascular system
Female
Radiology
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Intracranial Hemorrhages
Biomarkers
Magnetic Resonance Angiography
Subjects
Details
- Language :
- English
- ISSN :
- 20479980
- Volume :
- 3
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
- Accession number :
- edsair.doi.dedup.....42128f13f0cc51947c42b7370544aa26