Back to Search
Start Over
A Comprehensive Analysis of Common and Rare Variants to Identify Adiposity Loci in Hispanic Americans: The IRAS Family Study (IRASFS)
- Source :
- PloS one, vol 10, iss 11, PLoS ONE, PLoS ONE, Vol 10, Iss 11, p e0134649 (2015)
- Publication Year :
- 2015
- Publisher :
- Public Library of Science (PLoS), 2015.
-
Abstract
- Obesity is growing epidemic affecting 35% of adults in the United States. Previous genome-wide association studies (GWAS) have identified numerous loci associated with obesity. However, the majority of studies have been completed in Caucasians focusing on total body measures of adiposity. Here we report the results from genome-wide and exome chip association studies focusing on total body measures of adiposity including body mass index (BMI), percent body fat (PBF) and measures of fat deposition including waist circumference (WAIST), waist-hip ratio (WHR), subcutaneous adipose tissue (SAT), and visceral adipose tissue (VAT) in Hispanic Americans (nmax = 1263) from the Insulin Resistance Atherosclerosis Family Study (IRASFS). Five SNPs from two novel loci attained genome-wide significance (P
- Subjects :
- Aging
lcsh:Medicine
Adipose tissue
Genome-wide association study
Cardiovascular
Oral and gastrointestinal
0302 clinical medicine
2.1 Biological and endogenous factors
Aetiology
lcsh:Science
Adiposity
Cancer
2. Zero hunger
Genetics
0303 health sciences
Multidisciplinary
Single Nucleotide
Hispanic or Latino
Isocitrate Dehydrogenase
3. Good health
Stroke
Research Article
medicine.medical_specialty
Waist
General Science & Technology
030209 endocrinology & metabolism
Single-nucleotide polymorphism
Biology
Polymorphism, Single Nucleotide
03 medical and health sciences
Insulin resistance
Clinical Research
Internal medicine
medicine
Humans
Genetic Predisposition to Disease
Obesity
Polymorphism
Genetic Association Studies
Metabolic and endocrine
Nutrition
030304 developmental biology
Genetic association
Prevention
lcsh:R
Human Genome
Membrane Proteins
medicine.disease
Endocrinology
lcsh:Q
Body mass index
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- PLOS ONE
- Accession number :
- edsair.doi.dedup.....42131cc5bb0da95b816df53a5fcd94f9
- Full Text :
- https://doi.org/10.1371/journal.pone.0134649