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Study of the phase behavior of polyethylene glycol 6000-itraconazole solid dispersions using DSC
- Source :
- International journal of pharmaceutics. 272(1-2)
- Publication Year :
- 2003
-
Abstract
- The aim of the present study was to investigate the phase behavior of solid dispersions made up of PEG 6000 and itraconazole using DSC. Solid dispersions were prepared by solvent evaporation. DSC analysis of pure PEG 6000 showed three endothermic events, representing the melting transitions of the three different crystal modifications. It was shown that itraconazole decreased the formation of the polymer modifications with melting transitions at 56 and 59 degrees C but promoted the formation of the modification with a melting transition at 63 degrees C. All dispersions investigated showed the presence of crystalline itraconazole indicating that the drug is not molecularly dispersed in the polymer matrix. However, the presence of an endothermic peak in DSC curves of all solid dispersions at approximately 85-90 degrees C showed that at least a second phase of pure itraconazole is present also: glassy itraconazole. The protective effect of the polymer is clear at low concentration of drug since no recrystallisation exotherm can be detected. However, at drug concentrations at or above 80%, a recrystallization exotherm at approximately 117 degrees C can be detected. At least three different phases can be distinguished at room temperature: a polymer phase, crystalline itraconazole and glassy itraconazole. The findings of the present study thus demonstrate the coexistence of multiple drug phases in a solid dispersion.
- Subjects :
- Recrystallization (geology)
Materials science
Antifungal Agents
Chemistry, Pharmaceutical
Pharmaceutical Science
Polyethylene glycol
Phase Transition
law.invention
Polyethylene Glycols
Excipients
chemistry.chemical_compound
Differential scanning calorimetry
law
Phase (matter)
Organic chemistry
Crystallization
Solubility
chemistry.chemical_classification
Methylene Chloride
Calorimetry, Differential Scanning
Temperature
Polymer
chemistry
Chemical engineering
Solvents
Itraconazole
Dispersion (chemistry)
Subjects
Details
- ISSN :
- 03785173
- Volume :
- 272
- Issue :
- 1-2
- Database :
- OpenAIRE
- Journal :
- International journal of pharmaceutics
- Accession number :
- edsair.doi.dedup.....42142af2fc9d4cb2199ff9d4c691c976