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Synthesis of Ionizable Calix[4]arenes for Chelation of Selected Divalent Cations
- Source :
- Molecules; Volume 27; Issue 5; Pages: 1478
- Publication Year :
- 2022
-
Abstract
- Two sets of functionalised calix[4]arenes, either with a 1,3-crown ether bridge or with an open-chain oligo ether moiety in 1,3-position were prepared and further equipped with additional deprotonisable sulfonamide groups to establish chelating systems for selected cations Sr2+, Ba2+, and Pb2+ ions. To improve the complexation behaviour towards these cations, calix[4]arenes with oligo ether groups and modified crowns of different sizes were synthesized. Association constants were determined by UV/Vis titration in acetonitrile using the respective perchlorate salts and logK values between 3.2 and 8.0 were obtained. These findings were supported by the calculation of the binding energies exemplarily for selected complexes with Ba2+.
- Subjects :
- 10120 Department of Chemistry
1602 Analytical Chemistry
1601 Chemistry (miscellaneous)
calixarenes
barium
chelation
3002 Drug Discovery
Organic Chemistry
3003 Pharmaceutical Science
Pharmaceutical Science
Analytical Chemistry
Chemistry (miscellaneous)
1313 Molecular Medicine
540 Chemistry
Drug Discovery
Molecular Medicine
Physical and Theoretical Chemistry
1606 Physical and Theoretical Chemistry
1605 Organic Chemistry
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Molecules; Volume 27; Issue 5; Pages: 1478
- Accession number :
- edsair.doi.dedup.....421c61986cf85e56206ad874e7452b08