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Association of Body Mass Index with Endothelial Function in Asian Men
- Source :
- International Journal of Cardiology. 324:186-192
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- The association of body weight with cardiovascular events is still controversial. We evaluated the relationship between body mass index (BMI) and endothelial function.We measured flow-mediated vasodilation (FMD) and BMI in 7682 men. All participants were divided into four groups by BMI: underweight (18.5 kg/mMultiple logistic regression analysis revealed that overweight (OR: 1.30, 95% CI: 1.14-1.47; P 0.001) and obesity (OR: 1.40, 95% CI: 1.09-1.80; P = 0.009) were associated with an increased risk of a low quartile of FMD. In 5571 younger adults (60 years), overweight (OR: 1.34, 95% CI: 1.16-1.55; P 0.001) and obesity (OR: 1.37, 95% CI: 1.04-1.81; P = 0.03) were associated with an increased risk of a low quartile of FMD, and underweight (OR: 0.56, 95% CI: 0.35-0.89; P = 0.01) was associated with a reduced risk of a low quartile of FMD. In 2111 older adults (≥60 years), underweight (OR: 2.16, 95% CI: 1.22-3.80; P = 0.008) was associated with an increased risk of a low quartile of FMD, and overweight and obesity were not associated with a risk of a low quartile of FMD.In Asian men, endothelial function was impaired in the overweight and obesity groups compared with that in the normal weight group. The risk for endothelial dysfunction was higher in obese younger adults than in obese older adults. The association of BMI with endothelial function may be different in young and elderly men.http://www.umin.ac.jp (University Hospital Medical Information Network Clinical Trials Registry) (UMIN000012952).
- Subjects :
- Male
medicine.medical_specialty
030204 cardiovascular system & hematology
Overweight
Body Mass Index
03 medical and health sciences
0302 clinical medicine
Thinness
Risk Factors
Internal medicine
medicine
Humans
Obesity
030212 general & internal medicine
Endothelial dysfunction
Association (psychology)
Aged
business.industry
nutritional and metabolic diseases
medicine.disease
University hospital
Clinical trial
Underweight
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Body mass index
Subjects
Details
- ISSN :
- 01675273 and 00001295
- Volume :
- 324
- Database :
- OpenAIRE
- Journal :
- International Journal of Cardiology
- Accession number :
- edsair.doi.dedup.....422988c5650f32ed7a576f9386a52361