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Synthesis and Characterization of Chitosan Hydrogels Containing 5-Aminosalicylic Acid Nanopendents for Colon: Specific Drug Delivery
- Source :
- Journal of Pharmaceutical Sciences. 99:4955-4961
- Publication Year :
- 2010
- Publisher :
- Elsevier BV, 2010.
-
Abstract
- The main aim of this research was to develop and evaluate a multiparticulate system of Ac-poly(amidoamine)(PAMAM)(G4)-chitosan (CS) hydrogels exploiting pH-sensitive and specific biodegradability properties for colon-targeted delivery of 5-aminosalicylic acid (5-ASA). All formulations were evaluated for particle size, encapsulation efficiency, swellability, and in vitro drug release. The size of the hydrogel was found to nanorange. The integrity of 5-ASA in the release fraction was assessed using sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The CS-Ac-PAMAM hydrogel was developed based on the modulation of ratio show promise as a system for controlled delivery of drug.
- Subjects :
- Chitosan
Aminosalicylic acid
Chromatography
Colon
Anti-Inflammatory Agents, Non-Steroidal
Amidoamine
Pharmaceutical Science
Hydrogels
Hydrogen-Ion Concentration
Aminosalicylic Acid
Dosage form
chemistry.chemical_compound
Drug Delivery Systems
chemistry
Targeted drug delivery
Drug delivery
Self-healing hydrogels
Microscopy, Electron, Scanning
Animals
Nanoparticles
Organic chemistry
Electrophoresis, Polyacrylamide Gel
Particle Size
Drug carrier
Subjects
Details
- ISSN :
- 00223549
- Volume :
- 99
- Database :
- OpenAIRE
- Journal :
- Journal of Pharmaceutical Sciences
- Accession number :
- edsair.doi.dedup.....422d1514d3b69d5c691ceba3504492a0