Calculation of LDL apoB

Item does not contain fulltext OBJECTIVES: This study tests the validity of the Hattori formula to calculate LDL apoB based on plasma lipids and total apoB. METHODS: In 2178 patients in a tertiary care lipid clinic, LDL apoB calculated as suggested by Hattori et al. was compared to directly measured LDL apoB isolated by ultracentrifugation. RESULTS: In subjects with plasma triglycerides >/= 3.0 mmol/L, there was considerable discordance between calculated and measured LDL apoB. In all others, the relation between measured LDL apoB and calculated LDL apoB could be expressed as LDL apoB = 0.86 [total apoB - 0.9 TC (mg/dL) + 0.09 HDL-C (mg/dL) - 0.08 TG (mg/dL)] - 7.0 (r > 0.91; P < 0.0001). CONCLUSIONS: Our results indicate that LDL apoB can be calculated with reasonable accuracy when triglycerides are