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Electroacupuncture Prevents Cognitive Impairments by Regulating the Early Changes after Brain Irradiation in Rats
- Source :
- PLoS ONE, PLoS ONE, Vol 10, Iss 4, p e0122087 (2015)
- Publication Year :
- 2015
- Publisher :
- Public Library of Science (PLoS), 2015.
-
Abstract
- Cognitive impairments severely affect the quality of life of patients who undergo brain irradiation, and there are no effective preventive strategies. In this study, we examined the therapeutic potential of electroacupuncture (EA) administered immediately after brain irradiation in rats. We detected changes in cognitive function, neurogenesis, and synaptic density at different time points after irradiation, but found that EA could protect the blood-brain barrier (BBB), inhibit neuroinflammatory cytokine expression, upregulate angiogenic cytokine expression, and modulate the levels of neurotransmitter receptors and neuropeptides in the early phase. Moreover, EA protected spatial memory and recognition in the delayed phase. At the cellular/molecular level, the preventative effect of EA on cognitive dysfunction was not dependent on hippocampal neurogenesis; rather, it was related to synaptophysin expression. Our results suggest that EA applied immediately after brain irradiation can prevent cognitive impairments by protecting against the early changes induced by irradiation and may be a novel approach for preventing or ameliorating cognitive impairments in patients with brain tumors who require radiotherapy.
- Subjects :
- Male
Electroacupuncture
medicine.medical_treatment
Synaptophysin
lcsh:Medicine
Hippocampus
Hippocampal formation
Blood–brain barrier
Rats, Sprague-Dawley
Cognition
Neurotransmitter receptor
Animals
Medicine
lcsh:Science
Maze Learning
Spatial Memory
Multidisciplinary
biology
business.industry
Dentate gyrus
lcsh:R
Neurogenesis
Radiation Injuries, Experimental
medicine.anatomical_structure
Blood-Brain Barrier
Anesthesia
Dentate Gyrus
biology.protein
Cytokines
lcsh:Q
Cognition Disorders
business
Neuroscience
Research Article
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- PLOS ONE
- Accession number :
- edsair.doi.dedup.....424d4a7879ac11ea0892c90c8ce2d28f