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Effect of resveratrol on pancreatic oxygen free radicals in rats with severe acute pancreatitis
- Publication Year :
- 2006
- Publisher :
- Baishideng Publishing Group Co., Limited, 2006.
-
Abstract
- To investigate the therapeutic effects of resveratrol (RESV) as a free radical scavenger on experimental severe acute pancreatitis (SAP).Seventy-two male Sprague-Dawley rats were divided randomly into sham operation group, SAP group, and resveratrol-treated group. Pancreatitis was induced by intraductal administration of 0.1 mL/kg 4% sodium taurocholate. RESV was given intravenously at a dose of 20 mg/kg body weight. All animals were killed at 3, 6, 12 h after induction of the model. Serum amylase, pancreatic superoxide dismutase (SOD), malondialdehyde (MDA), and myeloperoxidase (MPO) were determined. Pathologic changes of the pancreas were observed under optical microscope.The serum amylase, pancreatic MPO and the score of pathologic damage increased after the induction of pancreatitis, early (3, 6 h) SAP samples were characterized by decreased pancreatic SOD and increased pancreatic MDA. Resveratrol exhibited a protective effect against lipid peroxidation in cell membrane caused by oxygen free radicals in the early stage of SAP. This attenuation of the redox state impairment reduced cellular oxidative damage, as reflected by lower serum amylase, less severe pancreatic lesions, normal pancreatic MDA levels, as well as diminished neutrophil infiltration in pancreas.RESV may exert its therapeutic effect on SAP by lowering pancreatic oxidative free radicals and reducing pancreatic tissue infiltration of neutrophils.
- Subjects :
- Male
medicine.medical_specialty
endocrine system diseases
genetic structures
Free Radicals
Neutrophils
Radical
chemistry.chemical_element
macromolecular substances
Resveratrol
Oxygen
Superoxide dismutase
Rats, Sprague-Dawley
chemistry.chemical_compound
Internal medicine
Malondialdehyde
Stilbenes
medicine
Animals
Pancreas
Peroxidase
biology
Superoxide Dismutase
organic chemicals
Gastroenterology
food and beverages
General Medicine
medicine.disease
Rats
medicine.anatomical_structure
Endocrinology
nervous system
chemistry
Pancreatitis
Acute Disease
biology.protein
Acute pancreatitis
Rapid Communication
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....4252869c88cbae58f8d2bf2d0e5e764b