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Microglia express a functional receptor for interleukin-23

Authors :
Jiangfeng Liang
Shijie Jin
Guiqin Zhang
Yoshifumi Sonobe
Tetsuya Mizuno
Akio Suzumura
Hideyuki Takeuchi
Source :
Biochemical and Biophysical Research Communications. 370:129-133
Publication Year :
2008
Publisher :
Elsevier BV, 2008.

Abstract

Interleukin (IL)-23 plays a predominant role in the development of autoimmune diseases by inducing IL-17-producing helper T (Th17) cells. The receptor for IL-23 consists of a heterodimer composed of the IL-12 receptor beta1 (IL-12Rbeta1) and the IL-23 receptor (IL-23R), which is mainly expressed on Th17 cells. A recent study showed that macrophages express IL-23R mRNA and can be distinguished from microglia by IL-23R expression. However, in this study, we show by RT-PCR and immunocytochemistry that microglia express IL-23R and IL-12Rbeta1 mRNA and protein, respectively. Additionally, microglia expressed a functional receptor for IL-23, as IL-23 enhanced the Interferon (IFN)-gamma-induced signal transducer and activator of transcription (STAT)1 phosphorylation and chemokine production. Thus, IL-23R expression does not discriminate peripheral macrophages from microglia. Moreover, since microglia produce IL-23, it may function in an autocrine manner to recruit inflammatory cells by inducing chemokine production.

Details

ISSN :
0006291X
Volume :
370
Database :
OpenAIRE
Journal :
Biochemical and Biophysical Research Communications
Accession number :
edsair.doi.dedup.....426cba73175777d8bbf629c07305dfd0
Full Text :
https://doi.org/10.1016/j.bbrc.2008.03.059