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Resectable adenocarcinomas in the pancreatic head: the retroperitoneal resection margin is an independent prognostic factor
- Source :
- BMC Cancer, BMC Cancer, Vol 8, Iss 1, p 5 (2008)
- Publisher :
- Springer Nature
-
Abstract
- Background The retroperitoneal margin is frequently microscopically tumour positive in non-curative periampullary adenocarcinoma resections. This margin should be evaluated by serial perpendicular sectioning. The aim of the study was to determine whether retroperitoneal margin involvement independently predicts survival after pancreaticoduodenectomy within a framework of standardized assessment of the resected specimens. Methods 114 consecutive macroscopically margin-free periampullary adenocarcinomas were examined according to a prospective standardized protocol for histopathologic evaluation. The retroperitoneal margin was assessed by serial perpendicular sectioning. The periampullary cancer origin (pancreas, ampulla, distal bile duct or duodenum) was registered prospectively and reevaluated retrospectively. Associations between histopathologic factors were evaluated by Chi-square test, Fisher's exact test, Kruskal-Wallis test, and Mann-Whitney test, as appropriate. Survival curves were calculated by the Kaplan-Meier method and compared using the log-rank test. Associations between histopathologic factors and survival were also evaluated by unadjusted and adjusted Cox regression analysis, including stepwise variable selection, in order to identify factors that independently predict a poor prognosis after periampullary adenocarcinoma resections. Results Microscopic resection margin involvement (R1 resection) was present in 40 tumours, of which 32 involved the retroperitoneal margin. Involvement of the retroperitoneal margin independently predicted a poor prognosis (p = 0.010; HR 1.89; CI 1.16–3.08) after presumed curative (R0 and R1) resection. In microscopically curative (R0) resections (n = 74), pancreatic tumour origin was the only factor that independently predicted a poor prognosis (p < 0.001; HR 4.71 for pancreatic versus ampullary; CI 2.13–10.4). Conclusion Serial perpendicular sectioning of the retroperitoneal resection margin demonstrates that tumour involvement of this margin independently predicts survival after pancreaticoduodenectomy for adenocarcinoma. Periampullary tumour origin is the only histopathologic factor that independently predicts survival in microscopically curative (R0) resections.
- Subjects :
- Adult
Male
medicine.medical_specialty
Ampulla of Vater
Cancer Research
medicine.medical_treatment
Adenocarcinoma
lcsh:RC254-282
Disease-Free Survival
Pancreaticoduodenectomy
medicine
Periampullary cancer
Genetics
Retroperitoneal space
Humans
Retroperitoneal Neoplasms
Retroperitoneal Space
Aged
Retrospective Studies
Aged, 80 and over
business.industry
Middle Aged
medicine.disease
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Prognosis
people.cause_of_death
Retroperitoneal Neoplasm
Surgery
Pancreatic Neoplasms
Periampullary Adenocarcinoma
medicine.anatomical_structure
Oncology
Resection margin
Female
Radiology
business
people
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 14712407
- Volume :
- 8
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- BMC Cancer
- Accession number :
- edsair.doi.dedup.....4279f3fc2d5e55cce8ef1c7977b5d131
- Full Text :
- https://doi.org/10.1186/1471-2407-8-5