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Vivosorb®, Bio-Gide®, and Gore-Tex®as barrier membranes in rat mandibular defects: an evaluation by microradiography and micro-CT
- Source :
- CLINICAL ORAL IMPLANTS RESEARCH, 19(5), 516-521. Wiley
- Publication Year :
- 2008
- Publisher :
- Wiley, 2008.
-
Abstract
- Objectives: The objectives of this study were to determine whether a new degradable synthetic barrier membrane (Vivosorb (R)) composed of poly(DL-lactide-epsilon-caprolactone) (PDLLCL) can be useful in implant dentistry and to compare it with collagen and expanded polytetrafluoroethylene (ePTFE) membranes.Material and methods: In 192 male Sprague-Dawley rats, a standardized 5 mm circular defect was created through the right angle of the mandible. New bone formation was evaluated by post-mortem microradiography and micro-CT (mu CT) imaging. Four groups (control, PDLLCL, collagen, ePTFE) were evaluated at three time intervals (2, 4, and 12 weeks). In the membrane groups the defects were covered; in the control group the defects were left uncovered. Data were analysed using a multiple regression model.Results: New bone formation could be detected by post-mortem microradiography in 130 samples and by mu CT imaging in 112 samples. Bone formation was progressive in 12 weeks, when the mandibular defect was covered with a membrane. Overall, more bone formation was observed underneath the collagen and ePTFE membranes than the PDLLCL membranes.Conclusions: In contrast to uncovered mandibular defects, substantial bone healing was observed in defects covered with a PDLLCL membrane. However, bone formation in PDLLCL-covered defects tended to be less than in the defects covered with collagen or ePTFE. The high variation in the PDLLCL samples at 12 weeks may be caused by the moderate adherence of this membrane to bone compared with collagen. These results indicate that further study is needed to optimize the properties of PDLLCL membranes.
- Subjects :
- Male
Bio-Gide (R)
Barrier membrane
Polyesters
Alveolar Bone Loss
Synthetic membrane
microradiography
Bone healing
micro-CT
artificial membrane
Rats, Sprague-Dawley
chemistry.chemical_compound
TISSUE REGENERATION
bone regeneration
Animals
Mandibular Diseases
Micro ct
Bone regeneration
Polytetrafluoroethylene
CONTROLLED SINGLE-BLIND
Mandible
Membranes, Artificial
Anatomy
RABBITS
Rats
GUIDED BONE REGENERATION
Membrane
chemistry
Guided Tissue Regeneration, Periodontal
COLLAGEN MEMBRANES
AUGMENTATION
Regression Analysis
GROWTH
Collagen
COMPUTED TOMOGRAPHY
Oral Surgery
Tomography, X-Ray Computed
NERVE GUIDES
STIMULATE OSTEOCONDUCTION
Biomedical engineering
Subjects
Details
- ISSN :
- 16000501 and 09057161
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Clinical Oral Implants Research
- Accession number :
- edsair.doi.dedup.....428200089db777c09437d2590463746f