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Effect on Mouse Liver Morphology of CeO2, TiO2 and Carbon Black Nanoparticles Translocated from Lungs or Deposited Intravenously
- Source :
- Applied Nano, Volume 2, Issue 3, Pages 16-241, Applied Nano, Vol 2, Iss 16, Pp 222-241 (2021), Modrzynska, J, Mortensen, A, Berthing, T, Ravn-Haren, G, Szarek, J, Saber, A T & Vogel, U 2021, ' Effect on Mouse Liver Morphology of CeO 2, TiO 2 and Carbon Black Nanoparticles Translocated from Lungs or Deposited Intravenously ', Applied Nano, vol. 2, no. 3, pp. 222-241 . https://doi.org/10.3390/applnano2030016
- Publication Year :
- 2021
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2021.
-
Abstract
- Exposure to nanoparticles by various routes results in size-dependent translocation of nanoparticles to the systemic circulation and subsequent accumulation in the liver. The purpose of this study was to determine possible adverse effects in the liver of long-lasting nanoparticle presence in the organ. Mice exposed to a single dose (162 µg/animal equivalent to 9 mg/kg body weight) of TiO2, CeO2 or carbon black nanoparticles by intratracheal instillation or intravenous injection, resulting in relatively low or high liver burdens, were followed for 1, 28 or 180 days. Clinical appearance, feed intake, body and liver weights, hematological indices, and transaminases and alkaline phosphatase activities were unaffected by exposure. Exposure-related foreign material persisted in the liver up to 180 days after intratracheal and intravenous exposure, mainly in sinusoids, near Kupffer cells, or around blood vessels. Increased incidences of histological findings after intratracheal or intravenous exposure included: initially, prominent nuclei of Kupffer cells, the apparent increase in binucleate hepatocytes (TiO2 and carbon black) and inflammatory infiltrations (CeO2)<br />later, cytoplasmic vacuolation, pyknosis and necrosis, especially for CeO2. Thus, neither low nor high nanoparticle burden in the liver affected enzymatic markers of liver injury, but indications of exposure-related necrotic changes, particularly for CeO2 nanoparticles, were noted.
- Subjects :
- Technology
Pathology
medicine.medical_specialty
hepatotoxicity
Necrosis
ALT
Geography, Planning and Development
tissue distribution
Chromosomal translocation
02 engineering and technology
010501 environmental sciences
Necrotic Change
01 natural sciences
medicine
Tissue Distribution
Pyknosis
Nanotoxicology
pyknosis
cerium oxide
AST
0105 earth and related environmental sciences
Liver injury
Chemistry
titanium dioxide
Hepatotoxicity
Cerium oxide
021001 nanoscience & nanotechnology
medicine.disease
3. Good health
liver histology
Titanium dioxide
Alkaline phosphatase
ALP
nanotoxicology
medicine.symptom
0210 nano-technology
Liver histology
Cytoplasmic Vacuolation
Subjects
Details
- Language :
- English
- ISSN :
- 26733501
- Database :
- OpenAIRE
- Journal :
- Applied Nano
- Accession number :
- edsair.doi.dedup.....42a4ebd0d0b7e9e0250c29f6beebbc5c
- Full Text :
- https://doi.org/10.3390/applnano2030016