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Treating Porcine Abscesses with Histotripsy: A Pilot Study
- Source :
- Ultrasound Med Biol
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Infected abscesses are walled-off collections of pus and bacteria. They are a common sequela of complications in the setting of surgery, trauma, systemic infections, and other disease states. Current treatment is typically limited to antibiotics with long-term catheter drainage, or surgical wash-out when inaccessible to percutaneous drainage or unresponsive to initial care efforts. Antibiotic resistance is also a growing concern. Although bacteria can develop drug resistance, they remain susceptible to thermal and mechanical damage. In particular, short pulses of focused ultrasound (i.e., histotripsy) generate mechanical damage through localized cavitation, representing a potential new paradigm for treating abscesses non-invasively, without the need for long-term catheterization and antibiotics. In this pilot study, boiling and cavitation histotripsy treatments were applied to subcutaneous and intramuscular abscesses developed in a novel porcine model. Ultrasound imaging was used to evaluate abscess maturity, for treatment monitoring and assessment of post-treatment outcomes. Disinfection was quantified by counting bacteria colonies from samples aspirated before and after treatment. Histopathological evaluation of the abscesses was performed to identify changes resulting from histotripsy treatment and potential collateral damage. Cavitation histotripsy was more successful in reducing the bacterial load while having a smaller treatment volume compared with boiling histotripsy. The results of this pilot study suggest focused ultrasound may lead to a technology for in situ treatment of acoustically accessible abscesses.
- Subjects :
- medicine.medical_specialty
Percutaneous
Acoustics and Ultrasonics
Swine
medicine.drug_class
medicine.medical_treatment
Antibiotics
Biophysics
Pilot Projects
Drug resistance
Article
Focused ultrasound
030218 nuclear medicine & medical imaging
03 medical and health sciences
Histotripsy
0302 clinical medicine
medicine
Animals
Radiology, Nuclear Medicine and imaging
Abscess
Ultrasonography, Interventional
Radiological and Ultrasound Technology
business.industry
Sequela
medicine.disease
High-intensity focused ultrasound
Disease Models, Animal
030220 oncology & carcinogenesis
High-Intensity Focused Ultrasound Ablation
Female
Radiology
business
Subjects
Details
- ISSN :
- 03015629
- Volume :
- 47
- Database :
- OpenAIRE
- Journal :
- Ultrasound in Medicine & Biology
- Accession number :
- edsair.doi.dedup.....42a7d56bd581a5e6e0188f61f0266eab