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Metronomic chemotherapy in anaplastic thyroid carcinoma: A potentially feasible alternative to therapeutic nihilism

Authors :
Mukesh Sharma
Swaroop Revannasiddaiah
Priyanka Thakur
Irappa Madabhavi
Anita Bodh
Source :
Indian Journal of Palliative Care, Indian Journal of Palliative Care, Vol 21, Iss 2, Pp 245-249 (2015)
Publication Year :
2015
Publisher :
Scientific Scholar, 2015.

Abstract

Anaplastic thyroid carcinoma (ATC) is one of the most aggressive malignancies and prognostic outlook remains very dismal. Treatment most often is palliative in intent attempting to relieve the patients from local compressive symptoms in the neck. Radical surgery, radiotherapy (RT), and chemotherapy have not been tested in large prospective trials, and current evidence from retrospective series and small trials indicate only marginal survival benefits. Given the poor prognostic and therapeutic outlook, patients must be encouraged to be actively involved in the decision making process. We report the case of an elderly patient who had no response to palliative RT, and was treated with oral metronomic chemotherapy. The response to oral metronomic chemotherapy was dramatic, and the patient has enjoyed complete freedom from symptoms as well as radiologically exhibits a complete regression. Thus, we document the first ever use of a simple, cost-effective, and convenient oral metronomic chemotherapeutic regimen delivering a remarkable response in an elderly patient with ATC.

Subjects

Subjects :
Oncology
Audiometric patterns
Intrathecal drug delivery system
medicine.medical_treatment
Bed sore
Case Report
Anaplastic thyroid cancer
Oral care
Iran
Breast cancer
Bedside ultrasound
Muslim religion
Body Tambura
Uncertainty in illness
Interventions
Mastectomy
Ultrasonography
Cancer
Decubitus ulcer
Outcome
Therapeutic nihilism
Depression
Health Policy
Celiac plexus block
Neurolytic
Radiation therapy
Acquired Immune Deficiency Syndrome
Knowledge
End-of-life care
Self-concept
lcsh:Medicine (General)
medicine.medical_specialty
Nursing
Guidelines
Education
Hope
Vertebroplasty
Regional cancer center
Yoga
Metronomic chemotherapy
Public Health, Environmental and Occupational Health
medicine.disease
Metronomic Chemotherapy
Regimen
Epidural opioids
Attitude
End of life
Severe pain
North West India
Qualitative study
Neurolysis
Evidence-based
Superior hypogastric
Volunteers
Sociodemographic parameters
Relaxation
Receptive music therapy
Continuing professional development
Educational program
Pressure ulcer
Social support
Palliative radiotherapy
Cancer pain
Hospice
Staff nurses
lcsh:R5-920
humanities
Palliative care
Mental health
Lumbar sympathectomy
174Behavioral intervention
Human Immunodeficiency Virus
Carcinoma prostate
Quality of life
Holistic care
Prevalence of pain
Pain
Stress
Home care
Anaplastic thyroid carcinoma
Qualitative research
Internal medicine
medicine
Chemotherapy
Radical surgery
Radiotherapy
Young age
business.industry
Cancer patients
Biological behavior
Burn survivors
Anaplastic carcinoma thyroid
Radiofrequency
Metronomic cyclophosphamide
Educational needs
Nursing students
Medical intervention
business

Details

ISSN :
09731075
Volume :
21
Database :
OpenAIRE
Journal :
Indian Journal of Palliative Care
Accession number :
edsair.doi.dedup.....42bf59efa4ba3d48a7e6efbf07716f6e
Full Text :
https://doi.org/10.4103/0973-1075.156511