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Regulatory Roles of Non-Coding RNAs in Colorectal Cancer
- Source :
- International Journal of Molecular Sciences, International Journal of Molecular Sciences, Vol 16, Iss 8, Pp 19886-19919 (2015)
- Publication Year :
- 2015
- Publisher :
- MDPI, 2015.
-
Abstract
- Non-coding RNAs (ncRNAs) have recently gained attention because of their involvement in different biological processes. An increasing number of studies have demonstrated that mutations or abnormal expression of ncRNAs are closely associated with various diseases including cancer. The present review is a comprehensive examination of the aberrant regulation of ncRNAs in colorectal cancer (CRC) and a summary of the current findings on ncRNAs, including long ncRNAs, microRNAs, small interfering RNAs, small nucleolar RNAs, small nuclear RNAs, Piwi-interacting RNAs, and circular RNAs. These ncRNAs might become novel biomarkers and targets as well as potential therapeutic tools for the treatment of CRC in the near future and this review may provide important clues for further research on CRC and for the selection of effective therapeutic targets.
- Subjects :
- dysregulation
RNA, Untranslated
Colorectal cancer
colorectal cancer
Antineoplastic Agents
Review
Biology
medicine.disease_cause
Bioinformatics
Catalysis
Inorganic Chemistry
lcsh:Chemistry
microRNA
medicine
Biomarkers, Tumor
Animals
Humans
Physical and Theoretical Chemistry
Molecular Biology
lcsh:QH301-705.5
Spectroscopy
Mutation
Organic Chemistry
Long ncRNAs
Cancer
biomarkers
General Medicine
Abnormal expression
medicine.disease
Computer Science Applications
Gene Expression Regulation, Neoplastic
lcsh:Biology (General)
lcsh:QD1-999
non-coding RNAs
targets
Colorectal Neoplasms
Subjects
Details
- Language :
- English
- ISSN :
- 14220067
- Volume :
- 16
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....42df35a88df673800aedb81e4743f218