Back to Search
Start Over
Use of nonsteroidal anti-inflammatory drugs and breast cancer risk in a prospective cohort of postmenopausal women
- Source :
- Breast Cancer Research, Breast Cancer Research, BioMed Central, 2020, 22 (1), ⟨10.1186/s13058-020-01343-1⟩, Breast Cancer Research, Vol 22, Iss 1, Pp 1-14 (2020), Breast Cancer Research : BCR
- Publication Year :
- 2020
- Publisher :
- HAL CCSD, 2020.
-
Abstract
- BackgroundAlthough anti-inflammatory agents could theoretically have anticancer properties, results from cohort studies on nonsteroidal anti-inflammatory drugs (NSAIDs) and breast cancer (BC) risk are inconsistent.MethodsWe investigated the association between NSAID use and BC incidence in the French E3N prospective cohort, which includes 98,995 women born between 1925 and 1950 and insured by a health insurance plan that covers mostly teachers. Self-reported information on lifestyle and medical history has been collected biennially by questionnaires and matched with data from a drug reimbursement database covering the period 2004–2014. Women who self-reported current NSAID use in the 2000 or 2002 questionnaires or with at least two reimbursements in any previous 3-month period were defined as exposed to NSAIDs. Multivariable Cox regression models were used to estimate hazard ratios (HRs) for the association of NSAID use with BC risk.ResultsIn the current analysis, 62,512 postmenopausal women were followed between 2004 and 2014 (9 years on average, starting at a mean age of 63 years; 2864 incident BC). In multivariable models, there was no statistically significant association between NSAID use and BC risk [HR = 1.00 (0.92–1.08), compared with non-exposed women]. The NSAID-BC associations did not differ by NSAID types, BC subtypes, risk factors, and comorbidities, nor by duration and dose of use. However, a statistically significant interaction was observed by proton pump inhibitor (PPI) drug use (Pinteraction = 0.01) whereby a decreased risk of BC with NSAID use was only observed among women who also used PPI before.ConclusionOnly women who used NSAIDs after having used PPI had a lower risk of BC. This result is novel and requires replication in other studies.
- Subjects :
- medicine.medical_specialty
Proton pump inhibitors
Breast Neoplasms
[SDV.CAN]Life Sciences [q-bio]/Cancer
Comorbidity
Lower risk
lcsh:RC254-282
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Breast cancer
Risk Factors
Surveys and Questionnaires
Internal medicine
medicine
Humans
Medical history
Prospective Studies
Prospective cohort study
Aged
Proportional Hazards Models
030304 developmental biology
0303 health sciences
Aspirin
business.industry
Proportional hazards model
Incidence
Incidence (epidemiology)
Anti-Inflammatory Agents, Non-Steroidal
Hazard ratio
Nonsteroidal anti-inflammatory drugs
Middle Aged
medicine.disease
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Postmenopausal women
3. Good health
Postmenopause
030220 oncology & carcinogenesis
Female
France
business
Research Article
Cohort study
Subjects
Details
- Language :
- English
- ISSN :
- 14655411
- Database :
- OpenAIRE
- Journal :
- Breast Cancer Research, Breast Cancer Research, BioMed Central, 2020, 22 (1), ⟨10.1186/s13058-020-01343-1⟩, Breast Cancer Research, Vol 22, Iss 1, Pp 1-14 (2020), Breast Cancer Research : BCR
- Accession number :
- edsair.doi.dedup.....43055a76e67b5b78bc6c0d2c7cae6b8f