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Primary myocardial disease in scleroderma—a comprehensive review of the literature to inform the UK Systemic Sclerosis Study Group cardiac working group
- Source :
- Bissell, L-A, Md Yusof, M Y & Buch, M H 2017, ' Primary myocardial disease in scleroderma-a comprehensive review of the literature to inform the UK Systemic Sclerosis Study Group cardiac working group ', Rheumatology (Oxford, England), vol. 56, no. 6, pp. 882-895 . https://doi.org/10.1093/rheumatology/kew364
- Publication Year :
- 2016
- Publisher :
- Oxford University Press (OUP), 2016.
-
Abstract
- Cardiac disease is prevalent in SSc and associated with a poor prognosis. Differentiating primary myocardial disease (SSc-cardiomyopathy) from ischaemic heart disease is difficult and the disease phenotype most at risk is unclear. A comprehensive literature review was performed to inform the UK Systemic Sclerosis Study Group for cardiac disease tasked with producing a best practice pathway for the management of cardiac disease in SSc. This review describes the prevalence of SSc-cardiomyopathy, its associated greater mortality and various manifestations (e.g. heart failure, arrhythmias and diastolic dysfunction). The limited evidence suggests SSc-cardiomyopathy is associated with other poor prognostic indicators, including diffuse cutaneous disease, positive SSc-specific serology, black ethnicity, older age at disease onset, tendon friction rubs, abnormal nail-fold capillaroscopy and worse quality-of-life scores. Differentiating SSc-cardiomyopathy from ischaemic heart disease requires well-planned studies. Non-invasive investigative techniques are improving the understanding of its pathophysiological basis.
- Subjects :
- Male
Cardiomyopathy
Disease
030204 cardiovascular system & hematology
Systemic scleroderma
Severity of Illness Index
Scleroderma
Electrocardiography
0302 clinical medicine
Pharmacology (medical)
Age of Onset
Child
skin and connective tissue diseases
Aged, 80 and over
integumentary system
Arrhythmias, Cardiac/diagnosis
Middle Aged
Prognosis
Echocardiography
Cardiology
Female
Cardiomyopathies
Adult
medicine.medical_specialty
Adolescent
Electrocardiography/methods
Echocardiography/methods
Cardiomyopathies/diagnosis
Diagnosis, Differential
Young Adult
03 medical and health sciences
Sex Factors
Rheumatology
Internal medicine
Severity of illness
medicine
Humans
Intensive care medicine
Aged
030203 arthritis & rheumatology
Scleroderma, Systemic
business.industry
Arrhythmias, Cardiac
medicine.disease
Scleroderma, Systemic/diagnosis
Heart failure
Quality of Life
Differential diagnosis
Age of onset
business
Magnetic Resonance Angiography
Subjects
Details
- ISSN :
- 14620332 and 14620324
- Database :
- OpenAIRE
- Journal :
- Rheumatology
- Accession number :
- edsair.doi.dedup.....430cabc3708e1e4734f727d74f016101