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Metal–Organic Frameworks as Efficient Oral Detoxifying Agents
- Source :
- Journal of the American Chemical Society
- Publication Year :
- 2018
-
Abstract
- Poisoning and accidental oral intoxication are major health problems worldwide. Considering the insufficient efficacy of the currently available detoxification treatments, a pioneering oral detoxifying adsorbent agent based on a single biocompatible metal-organic framework (MOF) is here proposed for the efficient decontamination of drugs commonly implicated in accidental or voluntary poisoning. Furthermore, the in vivo toxicity and biodistribution of a MOF via oral administration have been investigated for the first time. Orally administered upon a salicylate overdose, this MOF is able to reduce the salicylate gastrointestinal absorption and toxicity more than 40-fold (avoiding histological damage) while exhibiting exceptional gastrointestinal stability (
- Subjects :
- Biodistribution
Antidotes
Administration, Oral
02 engineering and technology
In vivo toxicity
Pharmacology
010402 general chemistry
01 natural sciences
Biochemistry
Catalysis
Health problems
Colloid and Surface Chemistry
Oral administration
Detoxification
Animals
Tissue Distribution
Rats, Wistar
Metal-Organic Frameworks
Aspirin
Chemistry
Salicylate overdose
Stomach
fungi
General Chemistry
021001 nanoscience & nanotechnology
Biocompatible material
3. Good health
0104 chemical sciences
Jejunum
Liver
Gastrointestinal Absorption
Toxicity
Female
Adsorption
Drug Overdose
0210 nano-technology
Subjects
Details
- ISSN :
- 00027863
- Database :
- OpenAIRE
- Journal :
- Journal of the American Chemical Society
- Accession number :
- edsair.doi.dedup.....430d444e506eadaae838536e5344eef2
- Full Text :
- https://doi.org/10.1021/jacs.8b04435