Comparison of genome-wide gene expression profiling by RNA Sequencing versus microarray in bronchial biopsies of COPD patients before and after inhaled corticosteroid treatment: does it provide new insights?

Authors :: Pieter S. Hiemstra
Gaik W. Tew
Hananeh Aliee
Benedikt Ditz
Maarten van den Berge
Jeunard Boekhoudt
Michele A. Grimbaldeston
Fabian J. Theis
Alen Faiz
Corry-Anke Brandsma
Martijn C. Nawijn
Victor Guryev
Wim Timens
Margaret Neighbors
Groningen Research Institute for Asthma and COPD (GRIAC)
Guided Treatment in Optimal Selected Cancer Patients (GUTS)
Computational Linguistics (CL)
Source :: ERJ Open Res. 7:00104-2021 (2021), ERJ Open Research, 7(2):00104-2021. European Respiratory Society, ERJ Open Research, Vol 7, Iss 2 (2021)
Publication Year :: 2021
Abstract: More DEGs are detected by RNA-Seq than microarrays in COPD lung biopsies and are associated with immunological pathways. Performing bulk tissue cell-type deconvolution in microarray lung samples, using the SVR method, reflects RNA-Seq results. https://bit.ly/2N8sY3s.

Language :: English
ISSN :: 23120541
Database :: OpenAIRE
Journal :: ERJ Open Res. 7:00104-2021 (2021), ERJ Open Research, 7(2):00104-2021. European Respiratory Society, ERJ Open Research, Vol 7, Iss 2 (2021)
Accession number :: edsair.doi.dedup.....4311e7e95c645c3fb1efe0bb18d8bf95
Full Text :: https://doi.org/10.1183/23120541.00104-2021

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