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Synchronous bone metastasis in lung cancer: retrospective study of a single center of 15,716 patients from Tianjin, China
- Source :
- BMC Cancer, Vol 21, Iss 1, Pp 1-9 (2021), BMC Cancer
- Publication Year :
- 2021
- Publisher :
- BMC, 2021.
-
Abstract
- Background This study aimed to describe the incidence, clinical characteristics, and prognosis of lung cancer patients with synchronous bone metastasis (SBM) and to analyze the prognostic factors of the lung cancer patients with SBM. Methods A total of 15,716 lung cancer patients who were diagnosed between 2009 to 2018 in the Tianjin Medical University Cancer Institute and Hospital were retrospectively reviewed. Among them, patients with SBM were checked. Both the demographic and clinical characteristics were included as follows: age, gender, marital status, history of smoking, alcohol consumption, family history of tumor, Karnofsky score, lymph node metastasis, histological type. Besides, laboratory data such as alkaline phosphatase, lactate dehydrogenase, carcinoembryonic antigen, squamous cell carcinoma antigen, cytokeratin-19 fragment, and neuron specific enolase were also included. The log-rank test and multivariate Cox regression analysis were employed to reveal the potential prognostic predictors. A further analysis using the Kaplan–Meier was employed to demonstrate the difference on the prognosis of LC patients between adenocarcinoma and non-adenocarcinoma. Results Among the included patients, 2738 patients (17.42%) were diagnosed with SBM. A total of 938 patients (34.3%) with SBM were successfully followed and the median survival was 11.53 months (95%CI: 10.57–12.49 months), and the 1-, 2-, and 5-year overall survival rate was 51, 17, and 8%, respectively. Multivariable Cox regression results showed history of smoking and high level of NSE were associated with the poor prognosis, while adenocarcinoma histological type was associated with better survival. Conclusion The prevalence of SBM in lung cancer is relatively high with poor survival. The lung cancer patients with SBM showed diverse prognosis. Among all the pathological types, the division of adenocarcinoma suggested different prognosis of the lung cancer patients with SBM. The present study emphasized the importance of pathological diagnosis on prognostic determinants in lung cancer patients with SBM.
- Subjects :
- 0301 basic medicine
Oncology
Male
Cancer Research
Lung Neoplasms
Kaplan-Meier Estimate
0302 clinical medicine
Carcinoembryonic antigen
Risk Factors
Prevalence
Family history
Lung
RC254-282
biology
Synchronous bone metastasis
Incidence
Lung Cancer
Bone metastasis
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Middle Aged
Prognosis
Survival Rate
030220 oncology & carcinogenesis
Adenocarcinoma
Female
Adult
medicine.medical_specialty
China
Adolescent
Adenocarcinoma of Lung
Bone Neoplasms
Risk Assessment
03 medical and health sciences
Young Adult
Internal medicine
Genetics
medicine
Humans
Lung cancer
Aged
Retrospective Studies
Proportional hazards model
business.industry
Research
Cancer
Retrospective cohort study
medicine.disease
030104 developmental biology
biology.protein
business
Follow-Up Studies
Subjects
Details
- Language :
- English
- ISSN :
- 14712407
- Volume :
- 21
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- BMC Cancer
- Accession number :
- edsair.doi.dedup.....431357609bea692695431796d7d1c973