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Efficacy of dimethyl fumarate treatment for moderate-to-severe plaque psoriasis: presentation extracts from the 29(th) EADV virtual congress, 29-31 October 2020
- Source :
- Expert Review of Clinical Immunology, r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol, instname, Expert Review of Clinical Immunology, 17, sup2, pp. 1-11, Expert Review of Clinical Immunology, 17, 1-11
- Publication Year :
- 2021
-
Abstract
- Contains fulltext : 235283.pdf (Publisher’s version ) (Open Access) Background: The 29th EADV Virtual Congress took place between the 29th-31st of October 2020. On October 29th, there was a Session on systemic treatment in which Professors Ulrich Mrowietz and Mar Llamas-Velasco presented the latest research on the efficacy of dimethyl fumarate (DMF) treatment for moderate-to-severe plaque psoriasis (BRIDGE and DIMESKIN 1 studies, respectively). The accepted DMF abstract from Professor Matthias Augustin, on the SKILL study, is also presented here. Results: Data from either prospective interventional (BRIDGE) or non-interventional (DIMESKIN 1, SKILL) studies among patients with moderate-to-severe psoriasis showed that DMF provides a positive efficacy profile in all four body regions included in the Psoriasis Area and Severity Index assessment (head and neck, trunk, upper and lower extremities) and a particularly interesting profile (strong efficacy) in the head and neck region. These findings may be of special interest to patients with scalp psoriasis who have been using topical therapies for a long time. Patient-reported outcomes (quality of life, pruritus) also improved during the 24 weeks of DMF treatment. The safety profile of DMF was similar to the previously described with fumaric acid esters. Conclusions: In summary, these results confirm the favorable efficacy and safety profile of DMF in long-term treatment.
- Subjects :
- 0301 basic medicine
Moderate to severe
medicine.medical_specialty
Immunology
efficacy
BRIDGE
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Quality of life
Psoriasis Area and Severity Index
Psoriasis
medicine
Immunology and Allergy
skill
030203 arthritis & rheumatology
Plaque psoriasis
dimethyl fumarate
Dimethyl fumarate
business.industry
psoriasis
medicine.disease
Dermatology
Safety profile
dimeskin 1
030104 developmental biology
chemistry
Inflammatory diseases Radboud Institute for Health Sciences [Radboudumc 5]
Body region
business
Subjects
Details
- ISSN :
- 1744666X and 17448409
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Expert Review of Clinical Immunology
- Accession number :
- edsair.doi.dedup.....4326a6fd99955bc9d219f26c4964504c