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Neuroglial and synaptic rearrangements associated with photic entrainment of the circadian clock in the suprachiasmatic nucleus
Neuroglial and synaptic rearrangements associated with photic entrainment of the circadian clock in the suprachiasmatic nucleus
- Source :
- European Journal of Neuroscience, European Journal of Neuroscience, 2010, 32 (12), pp.2133-42. ⟨10.1111/j.1460-9568.2010.07520.x⟩, European Journal of Neuroscience, Wiley, 2010, 32 (12), pp.2133-42. ⟨10.1111/j.1460-9568.2010.07520.x⟩
- Publication Year :
- 2010
- Publisher :
- HAL CCSD, 2010.
-
Abstract
- International audience; Rhythmic biological functions in mammals are orchestrated by a circadian timekeeper in the suprachiasmatic nucleus of the hypothalamus (SCN) which precisely adjusts clock outputs to solar time through the process of photic synchronization. Entrainment to the 24-h light-dark cycle is known to act on the molecular loops which trigger circadian oscillations but is also thought to involve day-night adjustments in the intercellular phasing of the multiple component SCN oscillators. This view is supported by data showing that the SCN undergoes important rearrangements of its neuroglial architecture throughout the 24-h cycle. The present paper highlights our data showing in rat that the two main sources of SCN efferents, composed of neurons synthesizing either vasopressin (AVP) or vasoactive intestinal peptide (VIP), are differentially involved in day-night SCN neuroglial plasticity. We found that the synaptic inputs received by the VIP neurons, which are major integrators of photic signals in the retinorecipient SCN subregion, increased during the day while those received by the AVP neurons remained unchanged at day and night. Glutamatergic axons, known to convey photic information from the retina, together with nonglutamatergic axons, contribute to the synaptic remodellings on VIP neurons. Experimental data providing strong indication that these plastic events may subserve synchronization of the clock to the light-dark cycle and that the daily fluctuations of plasma glucocorticoid hormones may act as temporal endocrine signals that may modulate SCN neuroglial plasticity through the rhythmic release of serotonin are also reviewed.
- Subjects :
- MESH: Suprachiasmatic Nucleus
MESH: Biological Clocks
MESH: Neurons
MESH: Arginine Vasopressin
MESH: Synapses
03 medical and health sciences
0302 clinical medicine
Biological Clocks
Animals
MESH: Animals
MESH: Circadian Rhythm
MESH: Neuronal Plasticity
[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM]
Glucocorticoids
030304 developmental biology
Neurons
0303 health sciences
Neuronal Plasticity
General Neuroscience
MESH: Vasoactive Intestinal Peptide
Circadian Rhythm
Arginine Vasopressin
MESH: Photic Stimulation
nervous system
Synapses
Suprachiasmatic Nucleus
MESH: Neuroglia
sense organs
MESH: Glucocorticoids
Neuroglia
030217 neurology & neurosurgery
Photic Stimulation
hormones, hormone substitutes, and hormone antagonists
Vasoactive Intestinal Peptide
Subjects
Details
- Language :
- English
- ISSN :
- 0953816X and 14609568
- Database :
- OpenAIRE
- Journal :
- European Journal of Neuroscience, European Journal of Neuroscience, 2010, 32 (12), pp.2133-42. ⟨10.1111/j.1460-9568.2010.07520.x⟩, European Journal of Neuroscience, Wiley, 2010, 32 (12), pp.2133-42. ⟨10.1111/j.1460-9568.2010.07520.x⟩
- Accession number :
- edsair.doi.dedup.....43407c21e184439e1c604ebbdb998883
- Full Text :
- https://doi.org/10.1111/j.1460-9568.2010.07520.x⟩