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Cardiac memory in humans: vectocardiographic quantification in cardiac resynchronization therapy
- Source :
- Clinical Research in Cardiology. 100:51-56
- Publication Year :
- 2010
- Publisher :
- Springer Science and Business Media LLC, 2010.
-
Abstract
- "Cardiac memory" (CM) refers to a change in repolarization induced by an altered pathway of activation. The effects of biventricular pacing on CM induction have not been investigated.To investigate the development of CM during cardiac resynchronization therapy (CRT) through vectorcardiography (VCG).Eleven patients undergoing CRT were enrolled. VCG was acquired during spontaneous ventricular activation at baseline and during AAI and DDD pacing immediately after and 7, 14, 21 and 60 days after the implantation.At 1-week follow-up, during AAI pacing T vector angles significantly changed (azimuth 23 ± 19°; p = 0.002; elevation 23 ± 27°; p = 0.019) and magnitude significantly increased (baseline 1.13 ± 0.69 mV; 7 days: 1.77 ± 1.27 mV; p = 0.026). T angle changes remained stable throughout the follow-up period while a further significant increase in magnitude was observed at 60 days (2.21 ± 1.50 mV; p = 0.01 vs. baseline and p = 0.04 vs. 7 days). Paced T vector magnitude at implant (2.24 ± 1.25 mV) decreased significantly at 7 days (1.64 ± 1.26 mV; p = 0.030) with a further significant decrease at 60 days (1.40 ± 1.18 mV; p = 0.003 vs. baseline; p = 0.02 vs. 7 days).CRT induces a significant change in T vector magnitude, azimuth, and elevation after resumption of spontaneous ventricular activation after 7 days from implantation. While further changes in T vector angle were not observed, after 2 months of CRT a significant decrease of paced T vector magnitude and a significant increase of spontaneous T vector magnitude were observed.
- Subjects :
- Male
medicine.medical_specialty
medicine.medical_treatment
Vectorcardiography
Cardiac resynchronization therapy
Cardiac Resynchronization Therapy
Heart Conduction System
Heart Rate
Internal medicine
Heart rate
Humans
Medicine
Repolarization
skin and connective tissue diseases
Aged
Aged, 80 and over
Heart Failure
medicine.diagnostic_test
business.industry
General Medicine
Middle Aged
medicine.disease
Adaptation, Physiological
Heart failure
cardiovascular system
Cardiology
Female
sense organs
Electrical conduction system of the heart
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 18610692 and 18610684
- Volume :
- 100
- Database :
- OpenAIRE
- Journal :
- Clinical Research in Cardiology
- Accession number :
- edsair.doi.dedup.....434202a8bddc6c363e77a36488b8b26f