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NOD2 prevents emergence of disease-predisposing microbiota
- Source :
- Gut microbes, Gut microbes, Taylor & Francis, 2013, 4 (4), pp.353-356. ⟨10.4161/gmic.25275⟩, Gut microbes, 2013, 4 (4), pp.353-356. ⟨10.4161/gmic.25275⟩
- Publication Year :
- 2013
- Publisher :
- HAL CCSD, 2013.
-
Abstract
- International audience; The gut flora is composed of a huge number of diverse, well-adapted symbionts that interact with epithelial lining throughout the host's entire life. Not all commensals have the same ability to maintain quiescent, protective inflammation. Importantly, instability in the composition of gut microbial communities (referred to as dysbiosis) has been linked to loss of gut barrier in the context of common human illnesses with increasing socio-economic impacts, such as Crohn disease and colorectal cancer. Our recent findings suggest that disease-predisposing dysbiosis can now be intentionally manipulated by targeting the major Crohn disease-predisposing NOD2 gene. That knowledge will not only add a new dimension to the often overlooked microbiology of Crohn disease and colorectal cancer, but will also have a broad impact on biomedical sciences worldwide.
- Subjects :
- Microbiology (medical)
Colorectal cancer
Context (language use)
colorectal cancer
[SDV.CAN]Life Sciences [q-bio]/Cancer
Disease
Biology
Gut flora
Microbiology
03 medical and health sciences
0302 clinical medicine
NOD2
medicine
030304 developmental biology
fecal transplantation
0303 health sciences
Crohn disease
nucleotide-binding oligomerization domain protein 2
Gastroenterology
dysbiosis
medicine.disease
Commensalism
biology.organism_classification
3. Good health
Infectious Diseases
Immunology
030211 gastroenterology & hepatology
Dysbiosis
Subjects
Details
- Language :
- English
- ISSN :
- 19490976 and 19490984
- Database :
- OpenAIRE
- Journal :
- Gut microbes, Gut microbes, Taylor & Francis, 2013, 4 (4), pp.353-356. ⟨10.4161/gmic.25275⟩, Gut microbes, 2013, 4 (4), pp.353-356. ⟨10.4161/gmic.25275⟩
- Accession number :
- edsair.doi.dedup.....4345b962f19b825f7bc42c4229b7a152