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Atrial natriuretic peptide regulates adipose tissue accumulation in adult atria
- Source :
- Proceedings of the National Academy of Sciences of the United States of America, Proceedings of the National Academy of Sciences of the United States of America, 2017, 114 (5), pp.E771-E780. ⟨10.1073/pnas.1610968114⟩, Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2017, 114 (5), pp.E771-E780. ⟨10.1073/pnas.1610968114⟩
- Publication Year :
- 2017
- Publisher :
- HAL CCSD, 2017.
-
Abstract
- International audience; The abundance of epicardial adipose tissue (EAT) is associated with atrial fibrillation (AF), the most frequent cardiac arrhythmia. However, both the origin and the factors involved in EAT expansion are unknown. Here, we found that adult human atrial epicardial cells were highly adipogenic through an epithelial-mesenchymal transition both in vitro and in vivo. In a genetic lineage tracing the WT1(CreERT2+/-)Rosa(tdT+/-)mouse model subjected to a high-fat diet, adipocytes of atrial EAT derived from a subset of epicardial progenitors. Atrial myocardium secretome induces the adipogenic differentiation of adult mesenchymal epicardium-derived cells by modulating the balance between mesenchymal Wingless-type Mouse Mammary Tumor Virus integration site family, member 10B (Wnt10b)/beta-catenin and adipogenic ERK/MAPK signaling pathways. The adipogenic property of the atrial secretome was enhanced in AF patients. The atrial natriuretic peptide secreted by atrial myocytes is a major adipogenic factor operating at a low concentration by binding to its natriuretic peptide receptor A (NPRA) receptor and, in turn, by activating a cGMP-dependent pathway. Hence, our data indicate cross-talk between EAT expansion and mechanical function of the atrial myocardium.
- Subjects :
- 0301 basic medicine
MAPK/ERK pathway
Male
Adipose tissue
Atrial natriuretic peptide
epicardial progenitors
Adipocytes
Myocytes, Cardiac
Receptor
Cells, Cultured
beta Catenin
Multidisciplinary
Adipogenesis
Stem Cells
Atrial fibrillation
Middle Aged
epicardial adipose tissue
Adipose Tissue
PNAS Plus
cardiovascular system
Female
Pericardium
Atrial Natriuretic Factor
medicine.medical_specialty
Epithelial-Mesenchymal Transition
MAP Kinase Signaling System
Mice, Transgenic
Biology
[SDV.GEN.GH] Life Sciences [q-bio]/Genetics/Human genetics
Diet, High-Fat
03 medical and health sciences
Internal medicine
Proto-Oncogene Proteins
atrial natriuretic peptide
medicine
Animals
Humans
Heart Atria
cardiovascular diseases
Aged
Mesenchymal stem cell
Mouse mammary tumor virus
medicine.disease
biology.organism_classification
Mice, Inbred C57BL
Wnt Proteins
cGMP
030104 developmental biology
Endocrinology
[SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics
Subjects
Details
- Language :
- English
- ISSN :
- 00278424 and 10916490
- Database :
- OpenAIRE
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America, Proceedings of the National Academy of Sciences of the United States of America, 2017, 114 (5), pp.E771-E780. ⟨10.1073/pnas.1610968114⟩, Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2017, 114 (5), pp.E771-E780. ⟨10.1073/pnas.1610968114⟩
- Accession number :
- edsair.doi.dedup.....435247545d228e0651499347a5ffabdc