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p16INK4a as a proliferation marker unrelated to HPV expression in odontogenic cysts and tumors
- Source :
- Journal of Oral Pathology & Medicine. 49:72-81
- Publication Year :
- 2019
- Publisher :
- Wiley, 2019.
-
Abstract
- p16INK4a is a tumor suppressor protein that retards cell cycle progression from G1 to S phase. Prior studies have evaluated p16INK4a expression in odontogenic keratocyst and ameloblastoma, but data regarding other odontogenic cysts and tumors have been sparse.With IRB approval, cases from the following entities were identified from archives of the UF Oral Pathology Biopsy Service (2005-2015): benign incidental odontogenic rest, dentigerous cyst, lateral periodontal cyst, calcifying odontogenic cyst, glandular odontogenic cyst, odontogenic keratocyst, orthokeratinized odontogenic cyst, adenomatoid odontogenic tumor, calcifying epithelial odontogenic tumor, and ameloblastoma. All cases were submitted for p16INK4a immunohistochemical testing.Results were scored as follows: nuclear and cytoplasmic staining of5% cells (score 0), 5%-25% (score 1), 25%-50% (score 2),50% (score 3). No significant difference in p16INK4a staining was noted between odontogenic cysts and the listed odontogenic tumors (chi-square, P = .540). When comparing lesions with higher recurrence rates (over 25% as reported in the literature) versus lesions with low recurrence rates (under 25%), higher recurrence correlated to significantly higher p16INK4a positivity (chi-square, P = .001). Follow-up testing was performed on 18 cases with "2" or "3" p16INK4a expression scores for high-risk HPV strains through HPV in situ hybridization (ISH) messenger RNA testing with no cases exhibiting a positive result.This study exhibits an association between increased p16INK4a positivity and odontogenic lesions with higher recurrence rates and highlights the role of p16INK4a as a progression marker unrelated to HPV expression in this group of pathologic entities.
- Subjects :
- Cancer Research
Pathology
medicine.medical_specialty
Dentigerous Cyst
Odontogenic Tumors
Pathology and Forensic Medicine
Ameloblastoma
03 medical and health sciences
Calcifying odontogenic cyst
0302 clinical medicine
medicine
Glandular odontogenic cyst
Humans
Keratocyst
neoplasms
business.industry
Adenomatoid odontogenic tumor
Lateral periodontal cyst
Papillomavirus Infections
030206 dentistry
medicine.disease
Calcifying epithelial odontogenic tumor
Dentigerous cyst
Otorhinolaryngology
030220 oncology & carcinogenesis
Odontogenic Cysts
Periodontics
Neoplasm Recurrence, Local
Oral Surgery
medicine.symptom
business
Subjects
Details
- ISSN :
- 16000714 and 09042512
- Volume :
- 49
- Database :
- OpenAIRE
- Journal :
- Journal of Oral Pathology & Medicine
- Accession number :
- edsair.doi.dedup.....43576beb40628c1eb722faa47425d899